KRTAP19-2 Inhibitors
KRTAP19-2 inhibitors refer to a class of chemical compounds designed to specifically inhibit the activity of keratin-associated protein 19-2 (KRTAP19-2). KRTAPs are structural proteins involved in the formation of hair, skin, and nails, interacting with keratins to maintain the mechanical strength and resilience of these tissues. KRTAP19-2, in particular, plays a role in the modulation of the keratin intermediate filaments in hair follicles, contributing to the overall structure and rigidity of hair fibers. Inhibitors of KRTAP19-2 are compounds that can bind to the protein and disrupt its normal interactions with keratins, resulting in alterations to the assembly of keratin filaments and potentially affecting the composition of hair fibers.
The chemical design of KRTAP19-2 inhibitors often involves structures that can either competitively block the binding sites of KRTAP19-2 or induce conformational changes that reduce its affinity for keratin filaments. These inhibitors may include small molecules, peptides, or other organic compounds tailored to interact with the unique protein domains of KRTAP19-2. By selectively targeting these regions, the inhibitors can modulate the functional properties of keratin fibers in experimental systems. The development of KRTAP19-2 inhibitors requires a deep understanding of the protein's structure, folding patterns, and interaction networks, allowing for the creation of molecules that can effectively interfere with its biological role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent may demethylate the promoter region of the KRTAP19-2 gene, leading to transcriptional repression and decreased protein levels. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor could strip acetyl groups from histones near the KRTAP19-2 gene, resulting in tighter chromatin and reduced transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
By inhibiting histone deacetylases, Suberoylanilide Hydroxamic Acid could create a chromatin environment around the KRTAP19-2 gene that is less conducive to gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
This compound might disrupt the acetylation pattern of histones associated with the KRTAP19-2 gene, which could downregulate its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could repress KRTAP19-2 gene expression by activating retinoic acid receptors that bind to the gene's regulatory elements, hindering its activity. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A may bind to DNA in the promoter region of KRTAP19-2, displacing transcription factors necessary for its expression and thus reducing protein synthesis. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
By targeting the Hedgehog signaling pathway, Cyclopamine could lead to a downregulation of the KRTAP19-2 gene if this pathway contributes to its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin might inhibit mTOR signaling, which could result in decreased synthesis of the KRTAP19-2 protein by altering gene expression pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibiting PI3K with LY 294002 could lead to a cascade effect culminating in the decreased expression of the KRTAP19-2 gene. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
By inhibiting JNK, SP600125 could decrease the activity of transcription factors for KRTAP19-2, leading to reduced expression of the gene. | ||||||