KRTAP12-1 Inhibitors
Chemical inhibitors of KRTAP12-1 can be understood as a diverse set of molecules that interfere with the protein's function by disrupting specific cellular processes or pathways essential for the protein's activity. Copper(II) sulfate and Zinc chloride act by perturbing the metal ion homeostasis that is crucial for the structural stability and activity of metal-dependent proteins like KRTAP12-1, effectively inhibiting their binding to essential substrates. Sodium orthovanadate targets protein tyrosine phosphatases, which would lead to its functional inhibition. Similarly, Alizarin Red S chelates calcium ions, which may be necessary for the functional integrity of KRTAP12-1, thus disrupting its activity.
Genistein, as a tyrosine kinase inhibitor, can prevent phosphorylation of proteins that are part of the regulatory network for KRTAP12-1, which is essential for its activity. PD98059 and U0126, both MEK inhibitors, can suppress the MAPK/ERK pathway, which would result in inhibition of the protein. LY294002 and Wortmannin, inhibitors of PI3K, would halt the PI3K/AKT signaling; these inhibitors would lead to its functional inhibition. SB203580's inhibition of p38 MAPK and SP600125's inhibition of JNK, both part of MAPK signaling pathways, would similarly interfere with the function of KRTAP12-1. Lastly, Cycloheximide disrupts protein synthesis, which would impede the production of KRTAP12-1, thereby reducing its functional presence in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate can inhibit the binding of metal-dependent proteins like KRTAP12-1 to their substrate by competing for the metal binding sites, which are crucial for the protein's structural integrity and function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc chloride can act as a functional inhibitor for metalloproteins such as KRTAP12-1 by altering the metal ion homeostasis in the cellular environment, which is necessary for the protein's activity and stability. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate inhibits protein tyrosine phosphatases, which could lead to an imbalance in phosphorylation states, affecting the activity of KRTAP12-1 if its function is regulated by phosphorylation. | ||||||
Alizarin | 72-48-0 | sc-214519 sc-214519A | 1.5 g 100 g | $21.00 $50.00 | ||
Alizarin Red S chelates calcium ions, potentially disrupting calcium-dependent protein functions. If KRTAP12-1 requires calcium for its structural or functional integrity, this chemical could inhibit its proper function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and could inhibit the phosphorylation of proteins that interact with or regulate KRTAP12-1, potentially leading to a functional inhibition of KRTAP12-1 if it relies on such interactions for its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which is part of the MAPK/ERK pathway. If KRTAP12-1 activity is ERK-dependent, inhibition of this pathway would result in decreased activity of KRTAP12-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor and would inhibit the PI3K/AKT pathway. If KRTAP12-1 function is dependent on signals propagated through this pathway, LY294002 would result in its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. If KRTAP12-1's function or stability is mediated through the p38 MAPK pathway, inhibition of this pathway would lead to the functional inhibition of KRTAP12-1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, another kinase in the MAPK/ERK pathway. Should KRTAP12-1's activity be contingent on the MAPK/ERK signaling, U0126 would block this signal transduction, leading to KRTAP12-1 inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. If the activity of KRTAP12-1 is PI3K-dependent, this inhibitor would lead to the functional inhibition of KRTAP12-1 by blocking the necessary PI3K signaling. | ||||||