KRTAP10-4 Inhibitors
Inhibitors of KRTAP10-4 include a spectrum of chemical entities that interfere with various cellular mechanisms, ultimately reducing the activity of this protein associated with hair keratin. Certain inhibitors result in the accumulation of metabolic byproducts, which may lead to structural alterations of the protein, affecting its stability or its integration with the keratin matrix. Others interfere with key signaling pathways responsible for protein phosphorylation, potentially impacting the protein's expression or its function within hair follicles. Some compounds specifically target the cytoskeleton, affecting the organization and function of structural components critical for maintaining the hair's structural integrity.
Additional agents exert their effects by disturbing the dynamics of structural proteins, which can indirectly influence KRTAP10-4's interactions with other proteins and its role in contributing to hair strength and resilience. Inhibition of protein synthesis by certain compounds can lead to decreased levels of KRTAP10-4, while interference with specific kinase signaling pathways might alter stress responses that regulate the protein's expression. Compounds that disrupt protein trafficking pathways may also impair the processing and localization of KRTAP10-4, and inhibitors that affect protein-protein interactions could disrupt its structural role in hair.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Aldehyde dehydrogenase inhibitor that elevates acetaldehyde levels, causing structural protein modifications and potentially altering KRTAP10-4's stability or integration with keratin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
GSK-3 inhibitor that can alter phosphorylation patterns, potentially impacting keratin dynamics and KRTAP10-4's interaction with keratin filaments. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase (MLCK) which is involved in cytoskeletal rearrangements, potentially disrupting keratin filament organization and KRTAP10-4's function. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Stabilizes F-actin filaments and may disrupt the cytoskeleton, indirectly affecting KRTAP10-4's role in the keratin infrastructure. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Tubulin polymerization inhibitor, which could alter cytoskeletal dynamics and indirectly affect the function of KRTAP10-4 in maintaining hair structure. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and disrupts normal cytoskeletal turnover, possibly impacting the interaction of KRTAP10-4 with other structural proteins in hair. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that can alter ERK pathway signaling, potentially modifying the expression and function of KRTAP10-4 in hair follicles. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits protein biosynthesis, which can lead to a reduction in the levels of KRTAP10-4 and other hair keratin-associated proteins. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that could alter stress response pathways, potentially affecting the expression and function of KRTAP10-4. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that can modify actin cytoskeleton organization, potentially disrupting KRTAP10-4's function in hair structure. | ||||||