KRTAP10-1 Inhibitors
Inhibitors of KRTAP10-1 exert their effects through a spectrum of biochemical interactions that lead to a decline in the protein's functional activity. These compounds destabilize the intricate protein structures that are essential for the maintenance of hair fiber strength and formation. For instance, certain inhibitors disrupt the delicate balance of metal ion concentrations critical for the tertiary structure of these proteins, resulting in conformational changes that undermine their role in hair formation. Other compounds can permeate cell membranes and destabilize protein-lipid interactions, leading to mislocalization and subsequent functional impairment of these proteins. Some inhibitors act by obstructing the normal intracellular transport processes, which are pivotal for the protein's contribution to hair structure, while others denature the protein by altering hydrophobic interactions, thus compromising the integrity of hair fibers.
The repertoire of inhibitory mechanisms continues with agents that cross-link protein molecules, hindering their integration into hair fibers, and substances that modify the protein's hydration shell and hydrogen bonds, vital for maintaining hair keratin structure. Additionally, there are inhibitors that target specific amino acid residues, such as serine, altering the protein's function in maintaining hair structural integrity. Exposure to certain compounds can lead to the unfolding of these proteins, preventing their correct folding and assembly into the hair matrix.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor known to affect phosphorylation processes. KRTAP10-1 function is dependent on phosphorylation for its structural role in hair follicles. Staurosporine's inhibition of kinases can result in decreased functionality of KRTAP10-1. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Targets microtubules and disrupts their dynamics. Since KRTAP10-1 is involved in keratin stabilization within hair follicles, the disruption of microtubule function can indirectly impair KRTAP10-1's structural role. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, thus potentially reducing the expression of KRTAP10-1 without affecting its transcription. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, inhibiting microtubule polymerization. As KRTAP10-1 requires cytoskeletal integrity for its function, colchicine can indirectly inhibit the proper function of KRTAP10-1 by disrupting the cytoskeleton. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that disrupts cytoskeletal proteins and can affect the structural network of keratins. This can lead to an indirect inhibition of KRTAP10-1 by altering the keratin infrastructure it associates with. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin and prevents its polymerization, thus affecting cytoskeletal stability. Given that KRTAP10-1 is part of the hair follicle's structural matrix, compromising actin structure can lead to its functional inhibition. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Acts as an actin filament disruptor, specifically severing filaments and preventing polymerization. This destabilizes the cytoskeletal framework necessary for KRTAP10-1 to function properly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that can affect actin cytoskeleton assembly. By inhibiting ROCK, the actin cytoskeleton can become disorganized, which is likely to indirectly inhibit KRTAP10-1, which relies on cytoskeletal integrity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule polymerization. KRTAP10-1's structural role can be compromised by the depolymerization of microtubules. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments and can induce actin polymerization, which paradoxically can disrupt actin dynamics. This disruption can lead to an indirect inhibition of KRTAP10-1 by affecting the actin cytoskeleton it depends on. | ||||||