Klotho Inhibitors
The class of Klotho inhibitors encompasses a diverse array of chemical compounds that exert their effects either directly on Klotho or indirectly by modulating key signaling pathways and cellular processes associated with Klotho functionality. These inhibitors offer valuable insights into the intricate regulatory networks that govern Klotho-mediated cellular responses. One group of Klotho inhibitors includes mTOR inhibitors such as Rapamycin, which modulates the mTOR signaling pathway. Its indirect impact on Klotho may occur through mTOR-mediated pathways, influencing cellular processes associated with Klotho function and the regulation of aging-related mechanisms. Furthermore, inhibitors like NF-κB Inhibitor (SN-50) and JSH-23 target the NF-κB signaling pathway. By inhibiting NF-κB, these compounds may indirectly modulate Klotho, potentially altering cellular responses associated with Klotho function and the inflammatory pathways in which Klotho participates. MEK inhibitors, including PD98059, U0126, and Trametinib, disrupt the MAPK/ERK signaling pathway. Their indirect impact on Klotho may occur through the MAPK/ERK pathway, influencing cellular processes associated with Klotho function and the regulation of various physiological responses.
PI3K inhibitors such as Wortmannin and LY294002 affect the PI3K/AKT signaling pathway, potentially influencing Klotho by modulating cellular processes associated with Klotho function and the regulation of various cellular functions, including apoptosis. In addition, inhibitors targeting specific kinases, such as SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor), and Trametinib (MEK inhibitor), showcase the complexity of cellular regulation connected to Klotho functionality. These compounds indirectly modulate Klotho by influencing signaling cascades associated with cellular stress, inflammation, and growth. In summary, the class of Klotho inhibitors provides a nuanced understanding of the regulatory mechanisms governing Klotho-mediated cellular responses. Whether by directly targeting Klotho or indirectly modulating key signaling pathways, these inhibitors contribute to the ongoing exploration of Klotho's role in cellular homeostasis and offer potential avenues for further investigation into the intricacies of Klotho-related biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, modulates the mTOR signaling pathway. Its indirect influence on Klotho may occur through mTOR-mediated pathways, impacting cellular processes associated with Klotho function and the regulation of aging-related mechanisms. | ||||||
NFκB Inhibitor | 213546-53-3 | sc-3060 sc-3060B sc-3060A | 0.5 mg 10 mg 5 mg | $166.00 $1269.00 $728.00 | 69 | |
SN-50, an inhibitor of NF-κB translocation, affects the NF-κB signaling pathway. By inhibiting NF-κB, SN-50 may indirectly modulate Klotho, potentially altering cellular responses associated with Klotho function and the inflammatory pathways in which Klotho participates. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor, disrupts the MAPK/ERK signaling pathway. Its indirect modulation of Klotho may occur through the MAPK/ERK pathway, influencing cellular processes associated with Klotho function and the regulation of various physiological responses. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, targets the JNK signaling pathway. Its indirect impact on Klotho may occur through JNK-mediated pathways, affecting cellular processes associated with Klotho function and the modulation of stress-related responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, affects the PI3K/AKT signaling pathway. Its indirect modulation of Klotho may occur through the PI3K/AKT pathway, influencing cellular processes associated with Klotho function and the regulation of various cellular functions, including apoptosis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, disrupts the p38 MAPK signaling pathway. Its indirect influence on Klotho may occur through the p38 MAPK pathway, impacting cellular processes associated with Klotho function and the regulation of stress-related responses and inflammation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, affects the PI3K/AKT signaling pathway. Its indirect modulation of Klotho may occur through the PI3K/AKT pathway, influencing cellular processes associated with Klotho function and the regulation of various cellular functions, including apoptosis. | ||||||
SP2509 | 1423715-09-6 | sc-492604 | 5 mg | $284.00 | ||
SP2509, a HSF1 inhibitor, targets the heat shock response. Its indirect influence on Klotho may occur through the inhibition of HSF1, impacting cellular processes associated with Klotho function and the regulation of stress-related responses and the heat shock response. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
JSH-23, an inhibitor of NF-κB translocation, affects the NF-κB signaling pathway. By inhibiting NF-κB, JSH-23 may indirectly modulate Klotho, potentially altering cellular responses associated with Klotho function and the inflammatory pathways in which Klotho participates. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Trametinib, a MEK inhibitor, disrupts the MAPK/ERK signaling pathway. Its indirect impact on Klotho may occur through the MAPK/ERK pathway, influencing cellular processes associated with Klotho function and the regulation of various physiological responses. | ||||||