Date published: 2025-10-7

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Klotho Antibodies

Santa Cruz Biotechnology features a diverse variety of Klotho monoclonal antibodies for research focused on understanding Klotho protein functions. Klotho monoclonal antibodies are suitable for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Klotho is a multifunctional protein that plays a significant role in regulating aging and longevity, as well as maintaining mineral homeostasis. Klotho is primarily expressed in the kidneys and brain, where it influences various signaling pathways, including those related to phosphate metabolism and oxidative stress. Research involving Klotho has revealed its importance in age-related diseases and metabolic disorders. Understanding Klotho's molecular mechanisms and cellular functions continues to be an active area of investigation in aging research. Exploring Klotho's role in disease progression helps identify potential therapeutic targets. Current research directions include investigating Klotho's involvement in calcium homeostasis and its protective effects against cellular stress. Santa Cruz Biotechnology monoclonal antibodies enable researchers to advance scientific understanding of Klotho's role in health and disease.

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Klotho Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Klotho Antibody (A-9)

sc-515942mouse IgG1 κ507-535 (h)WB, IP, IF, ELISAm, r, h
4
(3)

Klotho Antibody (F-5)

sc-515939mouse IgG2b κ119-143 (h)WB, IP, IF, ELISAh
4
(3)

Klotho Antibody (D-4)

sc-515940mouse IgG2b κ119-143 (h)WB, IP, IF, IHC(P), ELISAh

new

(0)

Klotho CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

betaKlotho CRISPR/Cas9 KO Plasmid (h)

sc-401614hGene KnockoutGFP0
(0)

betaKlotho HDR Plasmid (h)

sc-401614-HDRhHomology Directed RepairPuromycin0
(0)

betaKlotho Double Nickase Plasmid (h)

sc-401614-NIChGene KnockoutPuromycin0
(0)

betaKlotho Double Nickase Plasmid (h2)

sc-401614-NIC-2hGene KnockoutPuromycin0
(0)

betaKlotho CRISPR/Cas9 KO Plasmid (m)

sc-429890mGene KnockoutGFP0
(0)

betaKlotho HDR Plasmid (m)

sc-429890-HDRmHomology Directed RepairPuromycin0
(0)

betaKlotho Double Nickase Plasmid (m)

sc-429890-NICmGene KnockoutPuromycin0
(0)

betaKlotho Double Nickase Plasmid (m2)

sc-429890-NIC-2mGene KnockoutPuromycin0
(0)

Klotho CRISPR/Cas9 KO Plasmid (h)

sc-400970hGene KnockoutGFP
2
(0)

Klotho HDR Plasmid (h)

sc-400970-HDRhHomology Directed RepairPuromycin
2
(0)

Klotho Double Nickase Plasmid (h)

sc-400970-NIChGene KnockoutPuromycin
2
(0)

Klotho Double Nickase Plasmid (h2)

sc-400970-NIC-2hGene KnockoutPuromycin
2
(0)

Klotho CRISPR/Cas9 KO Plasmid (m)

sc-421290mGene KnockoutGFP
1
(0)

Klotho HDR Plasmid (m)

sc-421290-HDRmHomology Directed RepairPuromycin
1
(0)

Klotho Double Nickase Plasmid (m)

sc-421290-NICmGene KnockoutPuromycin
1
(0)

Klotho Double Nickase Plasmid (m2)

sc-421290-NIC-2mGene KnockoutPuromycin
1
(0)

Klotho CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

betaKlotho CRISPR Activation Plasmid (h)

sc-401614-ACThGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho CRISPR Activation Plasmid (h2)

sc-401614-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho Lentiviral Activation Particles (h)

sc-401614-LAChGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho Lentiviral Activation Particles (h2)

sc-401614-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho CRISPR Activation Plasmid (m)

sc-429890-ACTmGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho CRISPR Activation Plasmid (m2)

sc-429890-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho Lentiviral Activation Particles (m)

sc-429890-LACmGene ActivationPuro, Blast, Hygro0
(0)

betaKlotho Lentiviral Activation Particles (m2)

sc-429890-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Klotho CRISPR Activation Plasmid (h)

sc-400970-ACThGene ActivationPuro, Blast, Hygro
2
(0)

Klotho CRISPR Activation Plasmid (h2)

sc-400970-ACT-2hGene ActivationPuro, Blast, Hygro
2
(0)

Klotho Lentiviral Activation Particles (h)

sc-400970-LAChGene ActivationPuro, Blast, Hygro
2
(0)

Klotho Lentiviral Activation Particles (h2)

sc-400970-LAC-2hGene ActivationPuro, Blast, Hygro
2
(0)

Klotho CRISPR Activation Plasmid (m)

sc-421290-ACTmGene ActivationPuro, Blast, Hygro
1
(0)

Klotho CRISPR Activation Plasmid (m2)

sc-421290-ACT-2mGene ActivationPuro, Blast, Hygro
1
(0)

Klotho Lentiviral Activation Particles (m)

sc-421290-LACmGene ActivationPuro, Blast, Hygro
1
(0)

Klotho Lentiviral Activation Particles (m2)

sc-421290-LAC-2mGene ActivationPuro, Blast, Hygro
1
(0)

Klotho siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

betaKlotho siRNA (h)

sc-72645hGene SilencingN/A
2
(0)

betaKlotho shRNA Plasmid (h)

sc-72645-SHhGene SilencingPuromycin
2
(0)

betaKlotho shRNA (h) Lentiviral Particles

sc-72645-VhGene SilencingPuromycin
2
(0)

betaKlotho siRNA (m)

sc-72646mGene SilencingN/A
1
(0)

betaKlotho shRNA Plasmid (m)

sc-72646-SHmGene SilencingPuromycin
1
(0)

betaKlotho shRNA (m) Lentiviral Particles

sc-72646-VmGene SilencingPuromycin
1
(0)

Klotho siRNA (h)

sc-43883hGene SilencingN/A
5
(0)

Klotho shRNA Plasmid (h)

sc-43883-SHhGene SilencingPuromycin
5
(0)

Klotho shRNA (h) Lentiviral Particles

sc-43883-VhGene SilencingPuromycin
5
(0)

Klotho siRNA (m)

sc-77344mGene SilencingN/A0
(0)

Klotho shRNA Plasmid (m)

sc-77344-SHmGene SilencingPuromycin0
(0)

Klotho shRNA (m) Lentiviral Particles

sc-77344-VmGene SilencingPuromycin0
(0)