Klotho Antibody (D-4): sc-515940
- Klotho Antibody (D-4) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 119-143 within an internal region of Klotho of human origin
- recommended for detection of Klotho of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Klotho Antibody (D-4) for WB and IHC(P) applications. These reagents are now offered in bundles with Klotho Antibody (D-4) (see ordering information below).
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Klotho Antibody (D-4) is a mouse monoclonal IgG2b antibody that detects Klotho in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Klotho is a vital protein that functions as a co-receptor for fibroblast growth factors, playing a crucial role in regulating mineral metabolism and aging processes. Klotho′s presence is particularly significant in the kidneys and brain, where Klotho helps modulate calcium and phosphate homeostasis, thereby influencing bone health and cardiovascular function. Notably, Klotho′s deficiency is associated with accelerated aging phenotypes, such as arteriosclerosis and osteoporosis, highlighting Klotho′s importance in maintaining physiological balance. Anti-Klotho antibody (D-4) provides reliable detection of this essential protein, facilitating research into Klotho′s role in age-related diseases and potential therapeutic interventions.
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Klotho Antibody (D-4) References:
- Suppression of aging in mice by the hormone Klotho. | Kurosu, H., et al. 2005. Science. 309: 1829-33. PMID: 16123266
- MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells. | Liu, Y., et al. 2019. Mol Ther. 27: 1051-1065. PMID: 30853453
- Treating Systemic Klotho Deficiency. | Pastor, J. and Moe, OW. 2019. Am J Nephrol. 49: 410-412. PMID: 30982040
- Klotho, the elusive kidney-derived anti-ageing factor. | Sanchez-Niño, MD., et al. 2020. Clin Kidney J. 13: 125-127. PMID: 32297880
- Klotho Protein and Cardio-Vascular System. | Tyurenkov, IN., et al. 2021. Biochemistry (Mosc). 86: 132-145. PMID: 33832412
- Neuroprotective Role of Klotho on Dementia. | Ananya, FN., et al. 2023. Cureus. 15: e40043. PMID: 37425590
- Interaction of Klotho and sirtuins. | Rostamzadeh, F., et al. 2023. Exp Gerontol. 182: 112306. PMID: 37804921
- The current and emerging Klotho-enhancement strategies. | Poursistany, H., et al. 2024. Biochem Biophys Res Commun. 693: 149357. PMID: 38091839
- Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation. | Zhang, X., et al. 2024. Theranostics. 14: 420-435. PMID: 38164143
- Mutation of the mouse klotho gene leads to a syndrome resembling ageing. | Kuro-o, M., et al. 1997. Nature. 390: 45-51. PMID: 9363890
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Klotho Antibody (D-4) | sc-515940 | 200 µg/ml | $322.00 | |||
Klotho Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-538835 | 200 µg Ab; 10 µg BP | $361.00 | |||
Klotho Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-536514 | 200 µg Ab; 40 µg BP | $361.00 | |||
Klotho Antibody (D-4): m-IgG2b BP-HRP Bundle | sc-549993 | 200 µg Ab; 10 µg BP | $361.00 |