KLHL35 Inhibitors
KLHL35 inhibitors encompass a range of compounds that indirectly influence the activity of KLHL35 by targeting various signaling pathways and cellular processes. For instance, inhibitors of the MAPK/ERK pathway, such as U0126 and PD98059, can disrupt the signaling events that may be essential for the function of KLHL35. If KLHL35 requires phosphorylation through this pathway for its activity, these inhibitors could decrease KLHL35 function by preventing necessary phosphorylation events.
Other compounds, like the PI3K inhibitors LY294002 and Wortmannin, could diminish the stability or activity of KLHL35 by altering the PI3K/Akt signaling pathway, which is fundamental for numerous cellular processes including growth and survival. Proteasome inhibitors, such as MG132 and Lactacystin, might indirectly inhibit KLHL35 by causing an accumulation of proteins within the cell, which could disrupt the cellular milieu in which KLHL35 operates. Additionally, the inhibition of protein kinase C by Bisindolylmaleimide I could prevent phosphorylation that KLHL35 might require, leading to a decrease in its activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
An indolocarbazole that acts as a potent kinase inhibitor, including those kinases that phosphorylate KLHL26. Phosphorylation can be critical for protein stability or function; thus, staurosporine can lead to decreased KLHL26 activity by inhibiting its phosphorylation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A peptide aldehyde that inhibits proteasome and calpain activity. Since KLHL26 is part of a Cullin-RING E3 ligase complex, inhibition of the proteasome can lead to accumulation of its substrates, indirectly reducing KLHL26-mediated ubiquitination activity. | ||||||
SMER28 | 307538-42-7 | sc-222320 | 10 mg | $173.00 | ||
A small molecule enhancer of rapamycin that can disrupt autophagy pathways. As autophagy can regulate the degradation of ubiquitinated proteins, SMER3 inhibition of autophagy can lead to the accumulation of KLHL26 substrates, thereby inhibiting KLHL26's functional activity. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
A NEDD8-activating enzyme inhibitor that prevents neddylation, a process essential for the activity of Cullin-RING ligases of which KLHL26 is a part. By inhibiting neddylation, MLN4924 can inhibit the ubiquitin ligase activity of KLHL26. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor used to prevent the degradation of ubiquitinated proteins. By inhibiting the proteasome, Bortezomib can lead to the accumulation of KLHL26 ubiquitination substrates, thereby indirectly inhibiting KLHL26 activity. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
A specific inhibitor of the proteasome that also prevents the degradation of polyubiquitinated proteins. Lactacystin's inhibition of the proteasome can indirectly inhibit KLHL26 by causing the accumulation of its substrates. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
A quinone methide triterpene that can induce heat shock response and inhibit the proteasome. Induction of heat shock proteins can stabilize client proteins and reduce the need for KLHL26-mediated ubiquitination, thus inhibiting KLHL26 activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor that blocks the degradation of ubiquitinated proteins. By inhibiting the proteasome, Epoxomicin leads to the accumulation of KLHL26 substrates, resulting in the indirect inhibition of KLHL26's activity. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A steroidal lactone that inhibits proteasomal activity. Withaferin A's inhibition of the proteasome could lead to the accumulation of KLHL26's substrates, thereby reducing the functional activity of KLHL26. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
A RAF kinase inhibitor that also inhibits additional tyrosine kinases. By inhibiting kinases that may phosphorylate substrates of KLHL26, Sorafenib can indirectly inhibit KLHL26 activity by reducing the availability of its substrates. | ||||||