KLHL28 Activators
KLHL28 Activators encompass a range of compounds that influence various signaling pathways, culminating in the activation of KLHL28. For instance, certain activators are known to directly stimulate the production of second messengers such as cyclic AMP, which in turn activates protein kinase A. This kinase can phosphorylate a variety of substrates, including KLHL28, thereby modulating its activity. Additionally, other activators inhibit the breakdown of these second messengers, leading to their accumulation and a similar enhancement of KLHL28 activity. Some compounds act on G protein-coupled receptors that initiate cascades resulting in elevated cyclic AMP levels, again activating protein kinase A and influencing the activity of KLHL28. Moreover, specific inhibitors can prevent the degradation of cyclic AMP, leading to sustained signaling and potential activation of KLHL28 through phosphorylation.
On a different front, activators that modulate stress response pathways, such as those initiated by protein synthesis inhibitors or glycosylation inhibitors, can also lead to the indirect activation of KLHL28. These stress-induced signaling pathways might activate kinases that target KLHL28 or initiate adaptive cellular mechanisms that influence its activity. Furthermore, compounds that disrupt cellular homeostasis, such as calcium signaling, can activate calcium-dependent kinases, which may subsequently phosphorylate and activate KLHL28. Some activators exert their effects by modulating transcriptional pathways or by inhibiting enzymes like GSK-3, which can lead to the stabilization and potential activation of proteins relevant to KLHL28's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP enhances protein kinase A (PKA) activity, which can phosphorylate and thereby activate KLHL28 as part of cAMP-dependent signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increased levels of cAMP can enhance PKA activity and indirectly activate KLHL28. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Engages beta-adrenergic receptors, which stimulate adenylyl cyclase resulting in elevated cAMP levels. The cAMP activates PKA, potentially leading to the phosphorylation and activation of KLHL28. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Binds to its G protein-coupled receptors (GPCRs), which can result in the activation of adenylate cyclase and a subsequent rise in cAMP levels. This rise in cAMP can activate PKA and potentially lead to the activation of KLHL28. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Selective inhibitor of phosphodiesterase 4 (PDE4), which degrades cAMP. This inhibition leads to increased cAMP levels, activating PKA, and may result in the phosphorylation and activation of KLHL28. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs) such as JNK, which could then phosphorylate substrates including KLHL28, leading to its activation. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
N-linked glycosylation inhibitor that can induce the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress. ER stress activates several signaling pathways, potentially including the activation of KLHL28 through adaptive mechanisms. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor that disrupts calcium homeostasis leading to calcium-mediated signaling cascades. This can activate calcium-dependent kinases, which may indirectly lead to the activation of KLHL28. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates various signaling pathways including NF-kB, which can lead to the transcriptional activation of genes. This transcriptional activation may include factors that lead to the activation of KLHL28. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Sirtuin activator that can modulate signaling pathways such as AMPK. Activation of such pathways can lead to the phosphorylation and indirect activation of substrates like KLHL28. | ||||||