KLHDC9 Inhibitors

KLHDC9 Inhibitors are selected based on their potential to modulate cytoskeletal dynamics, actin organization, and cellular signaling pathways, which are relevant to the general functions of Kelch domain-containing proteins. Y-27632, free base, ML 141, (S)-(-)-Blebbistatin, CK 666, Wiskostatin, Latrunculin B, Latrunculia magnifica, Cytochalasin D, and SMIFH2 are chosen for their roles in modulating the actin cytoskeleton. These compounds can help in understanding the broader context of actin dynamics and potentially provide insights into the functions of Kelch domain-containing proteins like KLHDC9.

Taxol and Nocodazole target microtubule dynamics, which is another aspect of the cytoskeleton that could be relevant to the functions of Kelch proteins. NSC23766, a Rac1 inhibitor, and Tozasertib, an Aurora kinase inhibitor, are included for their potential to impact signaling pathways and cell division processes that might intersect with Kelch domain-containing protein functions. These inhibitors provide a broad approach to investigating the role of KLHDC9 in cellular processes, especially in the context of cytoskeletal organization and cellular signaling. However, specific functions of KLHDC9 and direct inhibitors targeting it would require further research and validation.