KLH-A Inhibitors
KLH-A, or Keyhole Limpet Hemocyanin A, is a large, copper-containing protein foudn in the hemolymph (a circulatory fluid) of the giant keyhole limpet (Megathura crenulata). It is widely used in immunology and vaccine research as an immunogenic carrier protein. KLH-A is particularly valuable due to its ability to stimulate a strong immune response when complexed with antigens, making it an essential component of various vaccines and immunization studies.One of the key features of KLH-A is its highly immunogenic nature. When an antigen, typically a small molecule or peptide that may not elicit a robust immune response on its own, is conjugated or attached to KLH-A, the resulting complex triggers a more potent immune reaction. This makes KLH-A an excellent choice for producing antibodies against specific antigens or haptens (small molecules that can't induce an immune response by themselves).
In vaccine development, KLH-A serves as a carrier protein to enhance the immune response against target antigens. By attaching antigens to KLH-A, researchers can create conjugate vaccines that are more effective at eliciting protective immune responses against diseases caused by bacteria or other pathogens.KLH-A has also been employed in basic immunological research to study the immune system's response to antigens and to investigate immune tolerance and autoimmune disorders.Overall, KLH-A plays a crucial role in immunology as a carrier protein that enhances the immunogenicity of attached antigens, making it invaluable for vaccine development, antibody production, and immunological studies. Its use has contributed to advances in understanding immune responses and has led to the development of vaccines against various diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus could inhibit mTOR, potentially down-regulating KLH-A expression as part of broader translational repression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
By inhibiting protein synthesis, cycloheximide could decrease overall levels of KLH-A protein. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D could bind DNA and inhibit transcription, potentially decreasing KLH-A mRNA synthesis. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Might crosslink DNA, disrupting transcription and thus the expression of KLH-A. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By inhibiting DNA topoisomerase I, camptothecin could affect DNA replication and transcription processes, influencing KLH-A expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
By inhibiting ribonucleotide reductase, it might affect DNA synthesis and subsequently KLH-A expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
May incorporate into nucleic acids and disrupt mRNA transcription, potentially affecting KLH-A expression. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
A CDK inhibitor, potentially affecting cell cycle progression and the expression of proteins like KLH-A. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
By causing DNA breaks, it might affect transcription and translation processes, including those of KLH-A. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
As a proteasome inhibitor, bortezomib might affect protein degradation, possibly influencing KLH-A levels. | ||||||