KKIALRE Inhibitors
Chemical inhibitors of KKIALRE include a range of compounds that primarily function by competing with ATP for the active site of the kinase, a strategy that effectively inhibits the enzyme's catalytic activity. Staurosporine, for instance, is known for its broad-spectrum kinase inhibition, and it achieves this by binding to the ATP-binding pocket of KKIALRE, thereby preventing the phosphorylation process that KKIALRE is responsible for. Similarly, 5-Iodotubercidin serves as an adenosine analog that competes for ATP binding sites, blocking the phosphorylating action of KKIALRE. Roscovitine and Purvalanol A, both selective inhibitors of cyclin-dependent kinases, also inhibit KKIALRE by binding to its active site, preventing the enzyme from catalyzing the transfer of phosphate groups which is essential for its function.
Furthermore, molecules like Indirubin-3'-monoxime and Olomoucine target KKIALRE by obstructing the ATP binding site, critically disrupting its activity. Flavopiridol similarly competes with ATP, essential for the kinase's activity, thereby inhibiting KKIALRE. PD 0332991, or palbociclib, and Dinaciclib both bind to the ATP-binding site of KKIALRE, preventing the phosphorylation that KKIALRE facilitates. AZD5438 inhibits KKIALRE by occupying the active site and preventing ATP from activating the enzyme. Ribociclib, another CDK inhibitor, obstructs the ATP binding site of KKIALRE, while Milciclib binds to the kinase domain, blocking ATP binding and thus KKIALRE activity. Collectively, these inhibitors utilize a consistent mechanism that involves direct interaction with the ATP-binding site of KKIALRE, blocking its essential phosphorylation function and effectively inhibiting the protein.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor that can inhibit KKIALRE by preventing ATP from binding to the kinase, thus blocking the phosphorylation process that KKIALRE typically mediates. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
This adenosine analog acts as an inhibitor of adenosine kinases and can inhibit KKIALRE by mimicking ATP and competing for its binding sites, thereby hindering KKIALRE's kinase activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a selective inhibitor of cyclin-dependent kinases and can inhibit KKIALRE by competing with ATP for binding to the kinase domain, preventing phosphorylation activities. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
This molecule is a known inhibitor of various cyclin-dependent kinases and can inhibit KKIALRE by obstructing the ATP-binding pocket of the kinase, thereby disrupting its catalytic activity. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine, a purine derivative, can inhibit KKIALRE by competing with ATP for the ATP-binding site on the kinase, thus impeding the phosphorylating action of KKIALRE. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
This is a selective inhibitor of cyclin-dependent kinases and can inhibit KKIALRE by binding to its active site and preventing the enzyme from catalyzing the transfer of phosphate groups. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits various cyclin-dependent kinases and can inhibit KKIALRE by competitively inhibiting ATP binding, which is necessary for KKIALRE's kinase activity. | ||||||
PD 0332991 Isethionate | 827022-33-3 | sc-478943 | 1 mg | $300.00 | ||
Also known as palbociclib, this chemical can inhibit KKIALRE by binding to its ATP-binding site, thus blocking the phosphorylation process that KKIALRE facilitates. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib is a strong inhibitor of CDKs and can inhibit KKIALRE by binding to the ATP pocket of the kinase, preventing ATP from activating the enzyme. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 can inhibit KKIALRE by competing with ATP for the active site of the kinase, thereby preventing the phosphorylation reactions normally carried out by KKIALRE. | ||||||