KIR2DS3 Activators
KIR2DS3 Activators encompass a spectrum of chemical entities that strategically enhance the functional activity of the KIR2DS3 protein through a variety of intracellular signaling pathways. Sodium orthovanadate and Pervanadate, by inhibiting tyrosine phosphatases, ensure a heightened state of phosphorylation for proteins within the signaling cascade that KIR2DS3 is a part of, potentially augmenting its activation status. Zinc gluconate contributes zinc ions, which are pivotal cofactors for kinases, thereby possibly enhancing the phosphorylation levels of KIR2DS3 or associated signaling proteins to increase KIR2DS3 activity. Magnesium chloride and Calcium chloride provide essential magnesium and calcium ions, respectively, which are necessary for the optimum function of various kinases and signaling molecules that could phosphorylate and activate KIR2DS3. Sodium fluoride acts as a serine/threonine phosphatase inhibitor, which could indirectly elevate the phosphorylation status of proteins interacting with KIR2DS3, resulting in its enhanced activation.
Furthermore, Lithium chloride, by inhibiting GSK-3, could induce a signaling environment conducive to KIR2DS3 activation due to shifts in phosphorylation patterns. Forskolin, through the elevation of cAMP levels, and IBMX, by preventing cAMP degradation, both potentiate PKA activity which may lead to phosphorylation events favoring KIR2DS3 activation. KN-93, a CaMKII inhibitor, may disrupt calcium/calmodulin-dependent signaling, leading to an indirect enhancement of KIR2DS3 function by altering the signaling equilibrium. Okadaic acid, targeting PP1 and PP2A, also tips the balance towards increased phosphorylation within the signaling networks, potentially benefiting KIR2DS3 activation. Similarly, Anisomycin, besides inhibiting protein synthesis, activates stress-activated protein kinases, which might promote signaling pathways facilitating the functional enhancement of KIR2DS3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate acts as a protein tyrosine phosphatase inhibitor. By inhibiting phosphatases, it promotes the phosphorylation state of tyrosine residues on proteins, which could enhance the signaling functions of KIR2DS3 through increased tyrosine phosphorylation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
As an essential trace element, zinc can act as a cofactor for various kinases. Zinc gluconate providing zinc ions might enhance the phosphorylation activity of kinases that phosphorylate KIR2DS3, leading to its increased functional activity. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium chloride provides magnesium ions which are essential cofactors for many enzymes, including those in signaling pathways. Adequate levels of Mg2+ could enhance the activity of kinases that phosphorylate KIR2DS3, thus potentially increasing its activation. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions play a crucial role in intracellular signaling. Calcium chloride can increase intracellular Ca2+ concentration, potentially activating calcium-dependent kinases that might phosphorylate KIR2DS3, leading to its enhanced function. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium fluoride is an inhibitor of serine/threonine phosphatases. By inhibiting these phosphatases, it might enhance serine/threonine phosphorylation of signaling molecules that are upstream or directly interact with KIR2DS3, thereby increasing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium ions inhibit glycogen synthase kinase 3 (GSK-3), which can lead to enhanced signaling through pathways that are potentially connected to KIR2DS3 activity by modulation of phosphorylation states of related proteins. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP can activate PKA, which may phosphorylate substrates that modulate KIR2DS3 signaling, thereby potentially enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. This elevation can activate PKA or PKG, which might influence signaling pathways that enhance the function of KIR2DS3. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII can shift the balance of signaling, potentially enhancing pathways that upregulate the activity of KIR2DS3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid acts as a potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Inhibition of these phosphatases can result in increased phosphorylation within various signaling pathways that might enhance KIR2DS3 activity. | ||||||