KIF27 Activators
KIF27, or kinesin family member 27, is part of the kinesin family of proteins, which are molecular motors that play critical roles in intracellular transport and cell division. These proteins move along microtubule networks within cells, transporting various cargoes, such as organelles, proteins, and RNA. KIF27, like other members of the kinesin superfamily, is believed to contribute to the precise organization of cellular components, especially during cell division and differentiation. The detailed function of KIF27, its interaction with specific cellular cargoes, and its regulation within the cell are areas of active research. Understanding the regulation of KIF27 expression is significant because it might provide insights into the fundamental mechanisms that govern cell motility, layout, and the integrity of cellular architecture.
The expression of KIF27, as with many genes, can be influenced by a variety of chemical activators that interact with cellular signaling pathways and transcriptional machinery. Certain compounds like retinoic acid could serve as activators, as it interacts with nuclear receptors that can bind to DNA and initiate transcription of target genes, which may include KIF27. Other compounds such as 5-Azacytidine could serve as an activator by reducing DNA methylation levels, thereby increasing the likelihood of transcription for genes like KIF27. Histone modifiers, like Trichostatin A and Sodium Butyrate, might upregulate KIF27 expression by altering chromatin structure and making the genomic region of KIF27 more accessible for transcription. Additionally, signaling molecules such as Forskolin and Phorbol 12-myristate 13-acetate could stimulate pathways that lead to the activation of transcription factors directly involved in the upregulation of KIF27. These chemical activators and their interactions with cellular processes illustrate the complexity of gene regulation and highlight the multitude of avenues through which the expression of vital proteins like KIF27 can be dynamically controlled.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate KIF27 by binding to its nuclear receptors, leading to a transcriptional cascade that increases the transcription of genes, including KIF27. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine can stimulate KIF27 expression due to the hypomethylation at the gene promoter, making it more permissive to transcriptional machinery. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could elevate KIF27 levels by preventing the deacetylation of histones near the KIF27 gene, ensuring an open chromatin state conducive to gene transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may prompt the activation of cAMP-dependent pathways, leading to the phosphorylation of CREB, which could directly bind to the KIF27 promoter and upregulate its expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can initiate a signaling cascade via PKC activation that leads to the transcriptional activation of genes such as KIF27 by altering promoter accessibility and enhancer activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride might stimulate KIF27 transcription by inhibiting GSK-3β, thereby activating Wnt/β-catenin signaling and leading to increased expression of downstream target genes including KIF27. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate might enhance KIF27 expression by altering cellular antioxidant response pathways that can lead to the activation of transcription factors promoting KIF27 gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate has the potential to stimulate KIF27 transcription by inhibiting histone deacetylases, resulting in a more relaxed chromatin structure around the KIF27 locus. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might increase KIF27 expression through glucocorticoid receptor-mediated activation of specific glucocorticoid response elements within the KIF27 promoter. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could potentiate KIF27 gene transcription by estrogen receptor-mediated activation, which can lead to the recruitment of coactivators to the KIF27 gene promoter. | ||||||