KIAA1432 Inhibitors
The term KIAA1432 inhibitors would refer to a class of compounds that directly or indirectly modulate the function or expression of the protein KIAA1432 through various mechanisms. The chemicals listed above represent a broad spectrum of compounds that target different kinases and enzymes involved in diverse cellular signaling pathways. These pathways can include PI3K/AKT/mTOR signaling, which is fundamental to cellular growth and survival; MAPK/ERK and p38 MAPK pathways, which regulate gene expression, cell division, and differentiation; JNK signaling, which is involved in stress responses; and cell cycle regulation through Aurora kinases. Additionally, the Rho-kinase pathway, targeted by Y-27632, is crucial for cytoskeletal dynamics and cell motility.
The variety of these compounds underscores the complex interplay of signaling networks within the cell, where a single protein like KIAA1432 can be influenced by multiple upstream and downstream factors. For instance, LY294002 and Wortmannin exert their effects by inhibiting PI3K, thereby potentially altering the phosphorylation state and activity of various substrates that could include or affect KIAA1432. Similarly, PD98059 and U0126, by inhibiting MEK, prevent the activation of ERK, a key transducer of mitogenic signals, which could indirectly impact KIAA1432's function if it is part of this pathway.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can modulate signal transduction processes and therefore may indirectly affect the activity of KIAA1432 if it is a substrate or regulator of specific kinase pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can alter the PI3K/AKT signaling cascade, potentially affecting proteins that are regulated by this pathway, including KIAA1432 if it is involved. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, which may indirectly influence the phosphorylation state of proteins like KIAA1432 if they are regulated by these phosphatases. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAP kinase inhibitor that can disrupt MAPK signaling pathways, potentially influencing the function of proteins involved in these pathways, such as KIAA1432. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which may affect proteins associated with the JNK signaling pathway, potentially including KIAA1432. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2, which may interfere with the ERK/MAPK signaling pathway, potentially affecting the activity of proteins like KIAA1432. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor that can disrupt the PI3K/AKT signaling cascade, potentially influencing proteins regulated by this pathway, like KIAA1432. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can affect the mTOR signaling pathway, potentially influencing the activity of proteins involved in this pathway, such as KIAA1432. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can affect protein degradation processes, potentially influencing the levels and activity of a wide range of proteins, including KIAA1432 if it is a proteasome substrate. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A broad-spectrum tyrosine kinase inhibitor that can affect various signaling pathways, potentially altering the function of proteins like KIAA1432 if they are affected by tyrosine kinase activity. | ||||||