KIAA0460 Inhibitors
The "Regulation of Nuclear Pre-mRNA Domain Containing 2" (RPRD2) protein plays a crucial role in the regulation of gene expression at the transcriptional level. It is a component of the RNAPII-associated factor 1 (PAF1) complex, which associates with RNA polymerase II (RNAPII) during transcription elongation. RPRD2 facilitates proper transcriptional elongation and mRNA processing by interacting with various components of the transcriptional machinery.RPRD2 is involved in the coordination of transcriptional events by promoting the efficient elongation of nascent RNA transcripts. It interacts with the C-terminal domain (CTD) of RNAPII and facilitates its phosphorylation, which is essential for the transition from transcription initiation to elongation. By facilitating this transition, RPRD2 ensures the proper processing of pre-mRNA transcripts, including splicing, 5' capping, and 3' end formation.
Additionally, RPRD2 contributes to the regulation of alternative splicing, which generates multiple mRNA isoforms from a single gene. It interacts with splicing factors and modulates their activity, thereby influencing the selection of splice sites and the production of alternative mRNA transcripts. This regulatory function of RPRD2 is crucial for generating transcriptomic diversity and regulating gene expression in response to various cellular signals and developmental cues.Furthermore, RPRD2 is implicated in the maintenance of genomic stability and the prevention of aberrant RNA processing events. Dysregulation of RPRD2 expression or function has been associated with various human diseases, including cancer and neurological disorders. Understanding the molecular mechanisms underlying the function of RPRD2 provides insights into the regulation of gene expression and the development of strategies for diseases associated with transcriptional dysregulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates DNA, preventing RNA polymerase activity, which inhibits transcription of the RNU2 gene encoding Regulation of Nuclear pre-mRNA Domain Containing 2 (RPRD2). | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin binds to bacterial RNA polymerase, impeding transcription initiation. Although it primarily targets bacteria, it may indirectly inhibit RPRD2 expression by affecting general transcriptional processes within cells. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil disrupts RNA synthesis by incorporating into RNA, leading to abnormal RNA function. Its interference with RNA metabolism could potentially inhibit the expression of RPRD2 mRNA. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C cross-links DNA, preventing DNA replication and transcription. Its cytotoxic effects on DNA could hinder the transcription of RNU2 gene, ultimately leading to the inhibition of RPRD2 expression. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine intercalates into DNA and interferes with topoisomerase II activity, resulting in DNA damage and inhibition of DNA replication and transcription. Consequently, RPRD2 expression could be hindered due to disrupted transcription. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms cross-links with DNA, inducing DNA damage and interfering with transcription. Its disruption of transcriptional processes could inhibit the expression of the RNU2 gene, leading to reduced RPRD2 levels. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits topoisomerase I, causing DNA damage and preventing DNA replication and transcription. The inhibition of transcription may result in decreased expression of the RNU2 gene, thereby inhibiting RPRD2 production. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, causing DNA damage and hindering transcription. By interfering with transcription, it may impede the expression of the RNU2 gene, leading to reduced levels of RPRD2. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-amanitin is a potent inhibitor of RNA polymerase II, halting mRNA synthesis. By blocking RNA polymerase II activity, it could prevent the transcription of the RNU2 gene, resulting in diminished expression of RPRD2. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin inhibits DNA polymerase α, δ, and ε, leading to stalled replication forks and inhibition of DNA synthesis. Its interference with DNA replication may indirectly suppress the transcription of the RNU2 gene, thus inhibiting RPRD2 expression. | ||||||