KIAA0141 Inhibitors
Chemical inhibitors classified as KIAA0141 Inhibitors do not directly target KIAA0141 but exert their influence on the protein indirectly by modulating the integrated stress response (ISR). The ISR is a cellular survival mechanism that adjusts protein synthesis in response to stress signals. DELE1, the protein encoded by the KIAA0141 gene, is involved in this response, and compounds affecting the ISR can thus affect DELE1 function. These inhibitors achieve their modulation by targeting various steps in the ISR pathway, such as the phosphorylation status of eIF2α, which is a central regulator of this response.
The compounds in this class act at different junctures of the ISR pathway. Some maintain the phosphorylated state of eIF2α, thereby sustaining the stress response which implicates DELE1's activity. Others work by inhibiting the downstream effects of eIF2α phosphorylation or by inducing endoplasmic reticulum (ER) stress, which in turn can activate the ISR. The ISR modulators include compounds that were originally developed for other uses, which have been found to influence the ISR.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal is a selective inhibitor of eIF2α dephosphorylation. It acts to sustain the phosphorylation state of eIF2α, thereby indirectly maintaining the ISR, which is connected to the function of DELE1. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
ISRIB reverses the effects of eIF2α phosphorylation, counteracting the inhibition of protein synthesis that is part of the ISR where DELE1 is involved. | ||||||
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $246.00 | ||
Guanabenz is known to activate the ISR by promoting eIF2α phosphorylation through an unclear mechanism that may involve inhibition of its dephosphorylation, thereby indirectly influencing DELE1's associated stress response. | ||||||
Sephin1 | 13098-73-2 | sc-507502 | 5 mg | $578.00 | ||
Sephin1 prolongs the ISR by selectively inhibiting stress-induced dephosphorylation of eIF2α. Its action can modulate the cellular processes involving DELE1. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
Nelfinavir, an HIV protease inhibitor, has been shown to induce ER stress and the ISR, which could indirectly affect DELE1's role in these pathways. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin induces ER stress and the subsequent ISR, which is part of the cellular context that DELE1 operates within. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a potent inducer of ER stress leading to the activation of the ISR, thus impacting the cellular environment of DELE1. | ||||||
Hemin chloride | 16009-13-5 | sc-202646 sc-202646A sc-202646B | 5 g 10 g 25 g | $102.00 $160.00 $326.00 | 9 | |
Hemin is known to activate HRI, which is involved in the phosphorylation of eIF2α, therefore influencing the ISR and the function of DELE1. | ||||||
GSK 2606414 | 1337531-36-8 | sc-490182 sc-490182A | 5 mg 25 mg | $163.00 $572.00 | ||
GSK2606414 is a PERK inhibitor that blocks one of the pathways leading to eIF2α phosphorylation, which could modulate the ISR and thus the activity of DELE1. | ||||||