KCNE3 Inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the KCNE3 protein. This protein, also known as potassium voltage-gated channel subfamily E regulatory subunit 3, plays a crucial role in regulating ion channels, specifically potassium channels, in various tissues. KCNE3 Inhibitors are designed to interact with the KCNE3 protein and exert an inhibitory effect on its function. The inhibition of KCNE3 by these compounds could lead to alterations in ion channel conductance and kinetics.
This class of inhibitors may function by directly binding to the KCNE3 protein, inducing conformational changes that hinder its normal regulatory activity on potassium channels. The modulation of KCNE3 activity through inhibition could have implications for cellular excitability, ion homeostasis, and possibly impact various physiological processes where potassium channels and their regulation are essential. Overall, KCNE3 Inhibitors represent a promising avenue for research into understanding the intricate mechanisms of ion channel modulation and their role in cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chromanol 293B | 163163-23-3 | sc-203889 sc-203889A | 10 mg 50 mg | $182.00 $774.00 | 1 | |
Blocks KCNE3 channel activity by binding to its external pore region. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Acts as a local anesthetic and can inhibit KCNE3 through membrane effects. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Broad-spectrum antifungal drug that can also inhibit ion channels like KCNE3. | ||||||
Verruculogen | 12771-72-1 | sc-204939 sc-204939A | 1 mg 5 mg | $116.00 $290.00 | ||
A mycotoxin that can inhibit KCNE3 and other ion channels. | ||||||
Terfenadine | 50679-08-8 | sc-208421A sc-208421B sc-208421 | 500 mg 1 g 5 g | $44.00 $71.00 $120.00 | ||
Antihistamine known to block KCNE3/Kv11.1 currents, with cardiac implications. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
Antiarrhythmic drug that affects multiple ion channels, including KCNE3. | ||||||