Date published: 2026-4-23

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KCNE3 Inhibitors

KCNE3 Inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the KCNE3 protein. This protein, also known as potassium voltage-gated channel subfamily E regulatory subunit 3, plays a crucial role in regulating ion channels, specifically potassium channels, in various tissues. KCNE3 Inhibitors are designed to interact with the KCNE3 protein and exert an inhibitory effect on its function. The inhibition of KCNE3 by these compounds could lead to alterations in ion channel conductance and kinetics.

This class of inhibitors may function by directly binding to the KCNE3 protein, inducing conformational changes that hinder its normal regulatory activity on potassium channels. The modulation of KCNE3 activity through inhibition could have implications for cellular excitability, ion homeostasis, and possibly impact various physiological processes where potassium channels and their regulation are essential. Overall, KCNE3 Inhibitors represent a promising avenue for research into understanding the intricate mechanisms of ion channel modulation and their role in cellular function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Chromanol 293B

163163-23-3sc-203889
sc-203889A
10 mg
50 mg
$182.00
$774.00
1
(1)

Blocks KCNE3 channel activity by binding to its external pore region.

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$51.00
$131.00
(0)

Acts as a local anesthetic and can inhibit KCNE3 through membrane effects.

Ketoconazole

65277-42-1sc-200496
sc-200496A
50 mg
500 mg
$63.00
$265.00
21
(1)

Broad-spectrum antifungal drug that can also inhibit ion channels like KCNE3.

Verruculogen

12771-72-1sc-204939
sc-204939A
1 mg
5 mg
$116.00
$290.00
(1)

A mycotoxin that can inhibit KCNE3 and other ion channels.

Terfenadine

50679-08-8sc-208421A
sc-208421B
sc-208421
500 mg
1 g
5 g
$44.00
$71.00
$120.00
(1)

Antihistamine known to block KCNE3/Kv11.1 currents, with cardiac implications.

Amiodarone

1951-25-3sc-480089
5 g
$318.00
(1)

Antiarrhythmic drug that affects multiple ion channels, including KCNE3.