Molecular structure of Verruculogen, CAS Number: 12771-72-1
Verruculogen (CAS 12771-72-1)
Alternate Names:
TR 1 toxin
Application:
Verruculogen is a neurotoxin that inhibits the M phase of the mammalian cell cycle
CAS Number:
12771-72-1
Molecular Weight:
511.57
Molecular Formula:
C27H33N3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Verruculogen is a neurotoxin that inhibits the M phase of the mammalian cell cycle. Inhibits Ca2+-activated K+ channels. Decreases GABA levels in CNS.
Verruculogen (CAS 12771-72-1) References
- Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B, paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds isolated from fermented meats. | Sabater-Vilar, M., et al. 2003. J Food Prot. 66: 2123-9. PMID: 14627292
- Production of the Tremorgenic Mycotoxins Verruculogen and Fumitremorgin B by Penicillium piscarium Westling. | Gallagher, RT. and Latch, GC. 1977. Appl Environ Microbiol. 33: 730-1. PMID: 16345234
- Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres. | Kosalec, I., et al. 2005. Acta Pharm. 55: 357-64. PMID: 16375825
- Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells. | Khoufache, K., et al. 2007. BMC Microbiol. 7: 5. PMID: 17244350
- FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus. | Steffan, N., et al. 2009. Org Biomol Chem. 7: 4082-7. PMID: 19763315
- What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. | Abad, A., et al. 2010. Rev Iberoam Micol. 27: 155-82. PMID: 20974273
- Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. | Mundt, K., et al. 2012. Chembiochem. 13: 2583-92. PMID: 23109474
- In vitro transformation of the tremorgenic mycotoxin verruculogen. | Bott, A., et al. 1992. Mycotoxin Res. 8: 2-8. PMID: 23605936
- Total Synthesis of Verruculogen and Fumitremorgin A Enabled by Ligand-Controlled C-H Borylation. | Feng, Y., et al. 2015. J Am Chem Soc. 137: 10160-3. PMID: 26256033
- Fate of TR-2, the hepatic metabolite of the tremorgenic mycotoxin verruculogen, in sheep. | Laws, I., et al. 1987. Xenobiotica. 17: 973-9. PMID: 3673112
- Neurobehavioral studies of tremorgenic mycotoxins verruculogen and penitrem A. | Sobotka, TJ., et al. 1978. Pharmacology. 16: 287-94. PMID: 643898
- Metabolism of verruculogen in rats. | Perera, KP., et al. 1982. Appl Environ Microbiol. 43: 503-8. PMID: 7041818
- Verruculogen Produced by soil fungi in England and Wales. | Patterson, DS., et al. 1981. Appl Environ Microbiol. 42: 916-7. PMID: 7316507
Inhibitor of:
KCNE3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Verruculogen, 1 mg | sc-204939 | 1 mg | $114.00 | |||
Verruculogen, 5 mg | sc-204939A | 5 mg | $284.00 |