Chromanol 293B (CAS 163163-23-3)
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Chromanol 293B operates as an influential agent in the modulation of ion channel activity, specifically targeting the slow delayed rectifier K+ current through its interaction with KCNQ1 channels. This action is critical for understanding the intricate mechanisms governing cardiac and neuronal excitability, offering a pivotal tool for research into the electrical properties of these tissues. Furthermore, Chromanol 293B extends its modulatory effects to the CFTR chloride current, a key component in the regulation of chloride ion transport across cellular membranes. This dual functionality not only broadens the spectrum of its applicability in experimental applications but also highlights its potential as a versatile molecule for dissecting the roles of these ion channels in various physiological processes. Through these mechanisms, Chromanol 293B serves as a vital instrument in the exploration of ion channel dynamics, contributing to the advancement of knowledge in cellular physiology and the underlying mechanisms of electrophysiological regulation.
Chromanol 293B (CAS 163163-23-3) References
- Rate- and site-dependent effects of propafenone, dofetilide, and the new I(Ks)-blocking agent chromanol 293b on individual muscle layers of the intact canine heart. | Bauer, A., et al. 1999. Circulation. 100: 2184-90. PMID: 10571978
- Time-dependent block of the slowly activating delayed rectifier K(+) current by chromanol 293B in guinea-pig ventricular cells. | Fujisawa, S., et al. 2000. Br J Pharmacol. 129: 1007-13. PMID: 10696102
- Electrophysiologic effects of the new I(Ks)-blocking agent chromanol 293b in the postinfarction canine heart. Preserved positive use-dependence and preferential prolongation of refractoriness in the infarct zone. | Bauer, A., et al. 2000. Basic Res Cardiol. 95: 324-32. PMID: 11005588
- Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. | Sun, ZQ., et al. 2001. J Cardiovasc Electrophysiol. 12: 472-8. PMID: 11332571
- Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current. | Bachmann, A., et al. 2001. Naunyn Schmiedebergs Arch Pharmacol. 363: 590-6. PMID: 11414653
- A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. | Seebohm, G., et al. 2001. Br J Pharmacol. 134: 1647-54. PMID: 11739240
- Vascular effects of class-III antiarrhythmic drugs: chromanol 293B, but not dofetilide blocks the smooth muscle delayed rectifier K+ channel. | Karle, CA., et al. 2002. Basic Res Cardiol. 97: 17-25. PMID: 11998973
- Effects of chromanol 293B on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. | Du, XL., et al. 2003. J Mol Cell Cardiol. 35: 293-300. PMID: 12676544
- Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells. | Lo, YC., et al. 2005. Life Sci. 76: 2275-86. PMID: 15748622
- Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel. | Bett, GC., et al. 2006. J Physiol. 576: 755-67. PMID: 16887873
- Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter. | Lerche, C., et al. 2007. Mol Pharmacol. 71: 1503-11. PMID: 17347319
- Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. | Cheng, HC. and Incardona, J. 2009. J Pharmacol Toxicol Methods. 60: 174-84. PMID: 19524054
- Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. | Neal, AM., et al. 2011. J Physiol. 589: 3595-609. PMID: 21576273
- Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulated insulin secretion and increases glucagon-like peptide-1 level in mice. | Liu, L., et al. 2014. Islets. 6: e962386. PMID: 25437377
- Differential effect of beta-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide, and chromanol 293B. | Schreieck, J., et al. 1997. J Cardiovasc Electrophysiol. 8: 1420-30. PMID: 9436780
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chromanol 293B, 10 mg | sc-203889 | 10 mg | $178.00 | |||
Chromanol 293B, 50 mg | sc-203889A | 50 mg | $759.00 |