Katanin p60 AL2 Inhibitors
Chemicals that fall under the class of Katanin p60 AL2 Inhibitors would be those that indirectly affect the activity of Katanin p60 AL2 by influencing microtubule dynamics or related cellular processes. Since Katanin p60 AL2's primary function is to sever microtubules, compounds that stabilize or destabilize microtubules can alter the substrate availability and therefore, the activity of Katanin p60 AL2.
Nocodazole and colchicine are microtubule-destabilizing agents; their action can lead to a reduction in the polymerized form of tubulin, which may result in a decreased ability of Katanin p60 AL2 to sever microtubules due to a lack of proper substrate. Conversely, compounds like paclitaxel, epothilone B, and taxol stabilize microtubules, making them resistant to disassembly and, as a result, can inhibit the severing action of Katanin p60 AL2 by reducing the need for its activity. Vinblastine, vincristine, podophyllotoxin, and combretastatin A-4 also bind tubulin but inhibit its polymerization, which can prevent the formation of microtubules, thereby reducing the functional influence of Katanin p60 AL2. Griseofulvin, mebendazole, and albendazole, on the other hand, interfere with microtubule function by different mechanisms, with the former disrupting the function of polymerized microtubules and the latter two inhibiting microtubule synthesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules by binding to β-tubulin, thus can indirectly inhibit Katanin p60 AL2 by disrupting its substrate. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and prevents their disassembly, which can inhibit Katanin p60 AL2 by reducing its ability to sever microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Binds tubulin and inhibits microtubule formation, which can indirectly inhibit Katanin p60 AL2 activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin, inhibiting microtubule polymerization and potentially reducing Katanin p60 AL2's ability to sever microtubules. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Stabilizes microtubules similarly to paclitaxel and can inhibit Katanin p60 AL2 by preventing microtubule disassembly. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Inhibits tubulin polymerization and can indirectly inhibit Katanin p60 AL2 by altering microtubule dynamics. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Binds tubulin and disrupts microtubule function, which can indirectly affect the activity of Katanin p60 AL2. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule function by interacting with polymerized microtubules, potentially inhibiting Katanin p60 AL2 indirectly. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Disrupts microtubule synthesis, affecting mitotic spindle formation, and can indirectly inhibit Katanin p60 AL2. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Similar to Mebendazole, it disrupts microtubule polymerization and can inhibit Katanin p60 AL2 indirectly. | ||||||