IZUMO4 Inhibitors
IZUMO4 inhibitors are a class of chemical compounds that indirectly impact the functional activity of IZUMO4, a protein known to play a critical role in the fusion of sperm and egg during fertilization. These inhibitors do not target IZUMO4 directly but instead modulate various signaling pathways that are essential for the proper functioning of IZUMO4. For instance, compounds like LY294002 and Wortmannin target theIZUMO4 inhibitors are a class of chemical compounds that indirectly impact the functional activity of IZUMO4, a protein known to play a critical role in the fusion of sperm and egg during fertilization. T
hese inhibitors do not target IZUMO4 directly but instead modulate various signaling pathways that are essential for the proper functioning of IZUMO4. For instance, compounds like LY294002 and Wortmannin target the PI3K/AKT pathway, which plays a pivotal role in cell survival and proliferation. The inhibition of PI3K leads to a decrease in AKT phosphorylation, which can create a suboptimal environment for processes that are dependent on IZUMO4. Similarly, the MAPK/ERK pathway is another target of these inhibitors, with U0126, PD98059, LY3214996, and PD0325901 acting as potent suppressors. The MAPK/ERK pathway is crucial for cell differentiation and proliferation, and its inhibition may reduce the expression of proteins necessary for the sperm-egg fusion process, thus indirectly affecting IZUMO4's role.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3Ks). PI3Ks are upstream regulators of the AKT signaling pathway, which is important for cell survival and proliferation. Inhibition of PI3K by LY294002 can lead to a reduction in AKT phosphorylation and activity, which may decrease the cell's capacity for processes that are essential for the fertilization event where IZUMO4 is known to play a role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of the MAPK/ERK pathway by inhibiting MEK1 and MEK2. As the MAPK/ERK pathway is involved in cell differentiation and proliferation, U0126 can indirectly result in decreased expression of proteins required for sperm-egg fusion, potentially affecting the functional activity of IZUMO4. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound is a specific inhibitor of p38 MAPK, which is involved in inflammatory responses and stress-activated pathways. By inhibiting p38 MAPK, SB203580 can indirectly influence the cellular environment that contributes to the regulation of proteins like IZUMO4, which is involved in the reproductive process. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent and irreversible inhibitor of PI3K, similar to LY294002 but with a different binding mechanism. Wortmannin's inhibition of PI3K can decrease AKT activation, similarly leading to an environment less conducive for the processes that require IZUMO4 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can disrupt the mTOR signaling pathway, which is crucial for protein synthesis and cell proliferation. Rapamycin's action can lead to a reduction in cellular activities that depend on the mTOR pathway, indirectly affecting the functional activity of IZUMO4 by altering the cellular context of gamete fusion. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which is part of the MAPK pathway. By inhibiting JNK, SP600125 can affect transcription factors and gene expression profiles, possibly leading to reduced functional activity of proteins involved in fertilization, such as IZUMO4. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Another MEK inhibitor that blocks the MAPK/ERK pathway. By preventing ERK activation, PD98059 can indirectly lead to reduced expression of proteins involved in reproductive processes, thereby potentially reducing IZUMO4 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A selective inhibitor of Src family kinases, which are involved in various signaling pathways, including those that regulate actin cytoskeleton dynamics—a process important for sperm motility and egg interaction. Inhibition of Src family kinases by PP2 can thus indirectly inhibit the functional activity of IZUMO4. | ||||||
LY3214996 | 1951483-29-6 | sc-507299 | 5 mg | $260.00 | ||
An ERK1 and ERK2 inhibitor that can suppress the MAPK/ERK pathway, leading to decreased proliferation and differentiation signals. This could indirectly reduce the functional activity of IZUMO4 by altering the expression of genes involved in the reproductive process. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
A dual mTORC1/mTORC2 inhibitor, which provides a broader inhibition of the mTOR pathway compared to Rapamycin. By thoroughly inhibiting mTOR signaling, AZD8055 can alter the cellular environment and indirectly affect the functional activity of IZUMO4. | ||||||