IZUMO2 Activators
IZUMO2 activators are chemicals that facilitate the sperm-egg fusion process by upregulating pathways involved in sperm maturation and function. These compounds could enhance the expression or functionality of IZUMO2 indirectly by creating a cellular environment that is conducive to fertilization. For example, cyclic AMP analogs can upregulate protein kinase A, an enzyme that phosphorylates various targets during sperm capacitation, leading to changes in sperm motility and the acrosome reaction.
Similarly, calcium ionophores directly increase intracellular calcium, a signal that is integral to the acrosome reaction and may be necessary for the proper positioning or function of IZUMO2 in the sperm membrane. Phosphodiesterase inhibitors, by preventing the breakdown of cAMP, support the maintenance of the capacitated state and could, therefore, sustain an environment where IZUMO2 activity is required. The bicarbonate ion serves as a natural modulator of the intracellular pH and cAMP levels in sperm, which are crucial for capacitation and may influence the IZUMO2 action.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that can bypass the cellular receptors and directly activate protein kinase A (PKA), potentially facilitating the phosphorylation events necessary for sperm capacitation that may influence IZUMO2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
By increasing intracellular Ca2+ levels, A23187 can induce the acrosome reaction, a step that might affect IZUMO2's positioning or function within the sperm membrane. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Directly activates adenylate cyclase, leading to an increase in cAMP levels and activation of PKA. This activation may promote sperm capacitation and indirectly enhance IZUMO2 activity. | ||||||
TPEN | 16858-02-9 | sc-200131 | 100 mg | $130.00 | 10 | |
A zinc chelator that can remove zinc ions from proteins and possibly affect the protein complex around IZUMO2, altering its function or stability. | ||||||
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $21.00 $29.00 $43.00 $84.00 $697.00 | 1 | |
As a physiological buffer, it raises intracellular pH and increases cAMP in sperm, which is required for capacitation, thereby potentially impacting IZUMO2. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Although primarily a hormone, synthetic progesterone can be considered a chemical that enhances sperm capacitation and the acrosome reaction, which may subsequently influence IZUMO2. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
While an inhibitor, it can be used to indirectly infer the involvement of PKA in capacitation by observing the downstream effects of PKA blockade, which may affect the state of IZUMO2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that can activate PKA, leading to the promotion of capacitation-related pathways that could indirectly enhance IZUMO2's activity. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $213.00 $865.00 | 4 | |
As a T-type calcium channel blocker, it could affect calcium fluxes during sperm capacitation and acrosome reaction, indirectly influencing IZUMO2 activity. | ||||||