ISYNA1 inhibitors belong to a specific chemical class designed to modulate the activity of the ISYNA1 enzyme. ISYNA1, also known as inositol-3-phosphate synthase 1, is a crucial enzyme involved in the biosynthesis of inositol, a fundamental component of phosphatidylinositol signaling pathways. The inhibition of ISYNA1 is of interest in various research fields due to its potential impact on cellular processes governed by inositol derivatives. The chemical structure of ISYNA1 inhibitors is designed to interact with the active site of the ISYNA1 enzyme, thereby disrupting its catalytic function. This class of inhibitors may exhibit diverse structural motifs, featuring key elements that facilitate binding to the enzyme and impede its normal enzymatic activity.
ISYNA1 inhibitors involves interfering with the conversion of glucose-6-phosphate to inositol-3-phosphate, a pivotal step in the inositol biosynthetic pathway. By obstructing this enzymatic process, ISYNA1 inhibitors may influence downstream signaling cascades and cellular functions that rely on inositol derivatives. The development and study of ISYNA1 inhibitors contribute to our understanding of the intricate regulatory networks governing cellular processes and may open avenues for further research into the broader implications of inositol metabolism. Researchers explore the structural diversity within the ISYNA1 inhibitors class to optimize their efficacy and specificity, providing valuable tools for probing the intricacies of cellular signaling pathways that involve inositol derivatives.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase, an enzyme downstream of ISYNA1 in the purine synthesis pathway. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Ribavirin is a nucleoside analogue that inhibits inosine monophosphate dehydrogenase, which can indirectly influence ISYNA1. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, affecting the availability of formyl groups needed for purine synthesis. | ||||||
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid | 137281-23-3 | sc-479733 | 250 mg | $330.00 | 1 | |
Pemetrexed inhibits several enzymes involved in purine and pyrimidine synthesis, indirectly affecting ISYNA1. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
6-Mercaptopurine interacts with the enzyme hypoxanthine-guanine phosphoribosyltransferase, impacting purine synthesis. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is metabolized to fluorodeoxyuridine monophosphate (FdUMP), which inhibits thymidylate synthase, affecting both purine and pyrimidine synthesis. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine is metabolized to 6-mercaptopurine, which inhibits purine synthesis. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Thioguanine is incorporated into DNA in place of guanine, causing DNA damage and impacting purine synthesis. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
Cladribine, a purine nucleoside analog, is incorporated into DNA, causing DNA damage and impacting purine synthesis. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
Clofarabine, a purine nucleoside analog, inhibits ribonucleotide reductase, impacting DNA synthesis and indirectly affecting ISYNA1. | ||||||