Date published: 2025-12-17

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ISYNA1 Inhibitors

ISYNA1 inhibitors belong to a specific chemical class designed to modulate the activity of the ISYNA1 enzyme. ISYNA1, also known as inositol-3-phosphate synthase 1, is a crucial enzyme involved in the biosynthesis of inositol, a fundamental component of phosphatidylinositol signaling pathways. The inhibition of ISYNA1 is of interest in various research fields due to its potential impact on cellular processes governed by inositol derivatives. The chemical structure of ISYNA1 inhibitors is designed to interact with the active site of the ISYNA1 enzyme, thereby disrupting its catalytic function. This class of inhibitors may exhibit diverse structural motifs, featuring key elements that facilitate binding to the enzyme and impede its normal enzymatic activity.

ISYNA1 inhibitors involves interfering with the conversion of glucose-6-phosphate to inositol-3-phosphate, a pivotal step in the inositol biosynthetic pathway. By obstructing this enzymatic process, ISYNA1 inhibitors may influence downstream signaling cascades and cellular functions that rely on inositol derivatives. The development and study of ISYNA1 inhibitors contribute to our understanding of the intricate regulatory networks governing cellular processes and may open avenues for further research into the broader implications of inositol metabolism. Researchers explore the structural diversity within the ISYNA1 inhibitors class to optimize their efficacy and specificity, providing valuable tools for probing the intricacies of cellular signaling pathways that involve inositol derivatives.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$68.00
$261.00
8
(1)

Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase, an enzyme downstream of ISYNA1 in the purine synthesis pathway.

Ribavirin

36791-04-5sc-203238
sc-203238A
sc-203238B
10 mg
100 mg
5 g
$62.00
$108.00
$210.00
1
(1)

Ribavirin is a nucleoside analogue that inhibits inosine monophosphate dehydrogenase, which can indirectly influence ISYNA1.

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

Methotrexate inhibits dihydrofolate reductase, affecting the availability of formyl groups needed for purine synthesis.

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid

137281-23-3sc-479733
250 mg
$330.00
1
(0)

Pemetrexed inhibits several enzymes involved in purine and pyrimidine synthesis, indirectly affecting ISYNA1.

6-Mercaptopurine

50-44-2sc-361087
sc-361087A
50 mg
100 mg
$71.00
$102.00
(0)

6-Mercaptopurine interacts with the enzyme hypoxanthine-guanine phosphoribosyltransferase, impacting purine synthesis.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

5-Fluorouracil is metabolized to fluorodeoxyuridine monophosphate (FdUMP), which inhibits thymidylate synthase, affecting both purine and pyrimidine synthesis.

Azathioprine

446-86-6sc-210853D
sc-210853
sc-210853A
sc-210853B
sc-210853C
500 mg
1 g
2 g
5 g
10 g
$199.00
$173.00
$342.00
$495.00
$690.00
1
(1)

Azathioprine is metabolized to 6-mercaptopurine, which inhibits purine synthesis.

6-Thioguanine

154-42-7sc-205587
sc-205587A
250 mg
500 mg
$41.00
$53.00
3
(1)

Thioguanine is incorporated into DNA in place of guanine, causing DNA damage and impacting purine synthesis.

2-Chloro-2′-deoxyadenosine

4291-63-8sc-202399
10 mg
$144.00
1
(0)

Cladribine, a purine nucleoside analog, is incorporated into DNA, causing DNA damage and impacting purine synthesis.

Clofarabine

123318-82-1sc-278864
sc-278864A
10 mg
50 mg
$185.00
$781.00
(0)

Clofarabine, a purine nucleoside analog, inhibits ribonucleotide reductase, impacting DNA synthesis and indirectly affecting ISYNA1.