ISG20L1 Activators
ISG20L1 Activators are a class of chemical compounds that influence various signaling pathways, leading to the enhanced functional activity of the ISG20L1 protein. Forskolin raises intracellular cAMP levels, which may enhance the activity of protein kinase A (PKA). PKA phosphorylation can influence various cellular processes, including the phosphorylation of transcription factors that regulate ISG20L1. PMA, by activating protein kinase C (PKC), could similarly affect transcriptional regulation, possibly leading to changes in ISG20L1 activity in relation to immune or stress signals. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium levels, affecting calcium-dependent kinases and phosphatases that can modulate proteins that interact with or regulate ISG20L1, thereby influencing its activity.
Further influencing ISG20L1 activity are inhibitors of specific kinases within major signaling pathways. U0126 and PD98059, both MEK inhibitors, alter the MAPK/ERK pathway's phosphorylation cascade, which may indirectly lead to increased ISG20L1 activity by affecting its regulatory mechanisms. SB203580, a p38 MAPK inhibitor, and SP600125, a JNK inhibitor, modulate cellular stress responses that could also enhance ISG20L1's role in innate immune pathways. Rapamycin's inhibition of mTOR might shift cellular signaling in a way that upregulates ISG20L1, especially in immune response pathways. LY294002, a PI3K inhibitor, affects cell survival and metabolic processes, altering ISG20L1's signaling context. BAY 11-7082 and curcumin both modulate NF-κB signaling, which could lead to changes in the immune response and influence the functional activity of ISG20L1 by altering the cellular environment and gene expression profiles connected to ISG20L1's role in antiviral responses or cell cycle regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels, which can enhance the activity of PKA. PKA phosphorylation can influence various cellular processes, potentially leading to the enhanced functional activity of ISG20L1 through cAMP responsive elements within its promoter region. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in multiple signaling pathways. This activation can lead to downstream effects on transcription factors that may increase ISG20L1 activity by enhancing its expression or functional engagement in response to stress or immune signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially modulating calcium-dependent protein kinases and phosphatases that can influence ISG20L1 activity by altering the phosphorylation state of proteins involved in its regulation or its substrate interactions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore, leading to increased intracellular calcium and activation of calcium-dependent signaling pathways, potentially enhancing the activity of ISG20L1 by similar mechanisms as ionomycin. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which affects protein synthesis and cell growth. Inhibition of mTOR can lead to a cellular state that enhances the activity of ISG20L1 by shifting the balance of signaling pathways and potentially upregulating ISG20L1's role in immune or stress response pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation, potentially changing the expression of genes involved in immune responses. This modulation can indirectly enhance the activity of ISG20L1 by affecting the cellular response to pathogens or inflammatory stimuli, which may rely on ISG20L1 for proper functioning. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to affect multiple signaling pathways, including inhibition of NF-κB. It can modulate the cellular environment in a way that may enhance the activity of ISG20L1 by altering gene expression profiles. | ||||||