INTU Inhibitors
INTU (inturned planar cell polarity protein) is a crucial component of the planar cell polarity (PCP) signaling pathway, a conserved signaling cascade that regulates the coordinated orientation of cells within epithelial tissues during development. In vertebrates, INTU is known to interact with other core PCP proteins, such as VANGL and FZD, to mediate cellular processes including cell migration, tissue morphogenesis, and organogenesis. Specifically, INTU plays a role in establishing the polarized distribution of cellular components along the axis perpendicular to the apical-basal axis of epithelial cells. This function is essential for proper tissue organization and patterning during embryonic development, as defects in PCP signaling can lead to a range of developmental abnormalities and congenital disorders.
Inhibition of INTU function can be achieved through various mechanisms aimed at disrupting its interactions with other PCP components or interfering with its signaling activity. One approach to inhibiting INTU is through the use of small molecule inhibitors that target its protein-protein interactions, preventing the formation of functional PCP protein complexes. Additionally, genetic or molecular techniques such as RNA interference or gene editing may be employed to suppress INTU expression levels, thereby reducing its availability for complex formation and downstream signaling. Furthermore, modulation of post-translational modifications or subcellular localization of INTU may also offer avenues for inhibiting its function within the PCP pathway. Overall, elucidating the mechanisms of INTU inhibition provides insights into its role in PCP signaling and its role as a target for interventions aimed at correcting PCP-related developmental defects.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine inhibits the Hedgehog (Hh) signaling pathway by targeting Smoothened (SMO). INTU is involved in the planar cell polarity pathway, which can intersect with Hh signaling. Inhibition of Hh signaling might indirectly modulate INTU activity. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT61 inhibits GLI-mediated transcription in the Hedgehog pathway. As INTU is part of the planar cell polarity pathway, altering Hh signaling could indirectly affect INTU's function. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine is another inhibitor of the Hedgehog signaling pathway. By modulating Hh signaling, Jervine could indirectly influence INTU's role in planar cell polarity. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole, an antifungal agent in research, has been shown to inhibit Smoothened in the Hedgehog pathway. This could indirectly affect INTU by altering cellular signaling pathways that intersect with planar cell polarity. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib is a Smoothened antagonist in the Hedgehog pathway. Its inhibition of this pathway might indirectly influence INTU's activity in planar cell polarity. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
SANT1 specifically targets Smoothened in the Hedgehog pathway. By inhibiting this pathway, SANT1 could indirectly affect INTU's function. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Purmorphamine activates Smoothened, which could lead to compensatory regulatory mechanisms in cellular signaling pathways, potentially affecting INTU indirectly. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Sonidegib inhibits Smoothened in the Hedgehog signaling pathway. Its modulation of this pathway could have indirect effects on INTU's role in planar cell polarity. | ||||||
RU-SKI 43 | 1043797-53-0 | sc-507508 | 5 mg | $395.00 | ||
RU-SKI 43 inhibits Hedgehog acyltransferase (Hhat), a key enzyme in Hedgehog signaling. This inhibition might indirectly affect INTU by altering signaling pathways that intersect with planar cell polarity. | ||||||
Saridegib | 1037210-93-7 | sc-507351 | 5 mg | $3500.00 | ||
Saridegib is a potent inhibitor of the Smoothened receptor in the Hedgehog pathway. Its influence on this pathway could indirectly modulate the function of INTU. | ||||||