Saridegib (CAS 1037210-93-7)
Alternate Names:
IPI-926 Patidegib
CAS Number:
1037210-93-7
Molecular Weight:
504.80
Molecular Formula:
C29H48N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Saridegib (CAS 1037210-93-7) References
- Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. | Lee, MJ., et al. 2012. Proc Natl Acad Sci U S A. 109: 7859-64. PMID: 22550175
- Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma. | Lo, WW., et al. 2014. Cancer. 120: 537-47. PMID: 24151134
- Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. | Justilien, V. and Fields, AP. 2015. Clin Cancer Res. 21: 505-13. PMID: 25646180
- Molecular docking approaches in identification of High affinity inhibitors of Human SMO receptor. | Akare, UR., et al. 2014. Bioinformation. 10: 737-42. PMID: 25670876
- Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. | Lauressergues, E., et al. 2016. Pharmacol Res Perspect. 4: e00214. PMID: 27069629
- Clinical Management of Locally Advanced Basal-Cell Carcinomas and Future Therapeutic Directions. | Niebel, D., et al. 2020. Dermatol Ther (Heidelb). 10: 835-846. PMID: 32383019
- The use of hedgehog antagonists in cancer therapy: a comparison of clinical outcomes and gene expression analyses. | Booker, BE., et al. 2020. Cancer Biol Ther. 21: 873-883. PMID: 32914706
- Basal Cell Carcinoma with Flexural Predilection in Basal Cell Nevus Syndrome. | Ashraf, R., et al. 2021. Indian Dermatol Online J. 12: 469-471. PMID: 34211923
- Cancer-associated fibroblasts as accomplices to confer therapeutic resistance in cancer. | Wang, W., et al. 2022. Cancer Drug Resist. 5: 889-901. PMID: 36627901
- Divergent and gram-scale syntheses of (-)-veratramine and (-)-cyclopamine. | Hou, W., et al. 2024. Nat Commun. 15: 5332. PMID: 38909052
Inhibitor of:
APCDD1L, C2CD3, DAND5, DISP1, HATH-1, hedgehog, HH, HHAT, Hhip, HHIPL2, HoxB5, Ihh, INTU, LELP1, LMBR1, LMBR1L, MESP2, patched, patched 2, PTCHD1, PTCHD2, PTCHD3, PTCHD4, Shh, smoothened, Su(fu), and VAX1.Activator of:
Dhh.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Saridegib, 5 mg | sc-507351 | 5 mg | $3500.00 |