INTS4 Activators
The INTS4 activators encompass chemicals affecting different cellular and biochemical pathways related to gene expression and RNA processing. Key among them are DNA methyltransferase like 5-Azacytidine and RG108. These chemicals modulate gene transcription, creating variable demands on the Integrator complex, in which INTS4 is a component. Such dynamics indicate the of these to indirectly influence the function and involvement of INTS4 in RNA processing. Similarly, histone modification plays a pivotal role in gene regulation. Chemicals such as C646, a specific p300/CBP histone acetyltransferase, and MS-275, an HDAC, showcase this principle. The Integrator complex's demand can be influenced by these as they alter the gene expression landscape. Methylation, another vital epigenetic mark, is targeted by chemicals like BIX-01294, EPZ004777, UNC0638, and A-366. Each of these affects either G9a or DOT1L methyltransferases, indirectly modulating INTS4 if its function or the Integrator complex activity relates to genes controlled by these methyltransferases.
Furthermore, p53, a crucial transcription factor governing various cellular processes, can also influence the Integrator complex's dynamics. Nutlin-3, by stabilizing p53, showcases how alterations in transcription factor levels can influence the broader RNA processing machinery, including INTS4's role. Lastly, BRD4-p300 interaction is crucial for certain gene expression processes, and YF2's ability to disrupt this interaction represents another avenue through which INTS4's function can be indirectly modulated. Each chemical in this class underscores the complex web of gene regulation and RNA processing and how intricate changes can reverberate across systems to influence specific protein functions, such as that of INTS4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that promotes gene transcription. By affecting global gene expression, it can indirectly influence the demand on the Integrator complex and consequently modulate INTS4 function. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a specific p300/CBP histone acetyltransferase inhibitor. If INTS4 function is tied to genes affected by p300/CBP-mediated histone acetylation, C646 can influence INTS4's involvement. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is an HDAC inhibitor that promotes gene transcription. Through the indirect modulation of gene transcription, the Integrator complex, including INTS4, can experience differential demands. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 inhibits G9a methyltransferase, affecting gene silencing. By modulating genes affected by G9a-mediated methylation, it can indirectly influence INTS4's role in the Integrator complex. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a DOT1L inhibitor, affecting H3K79 methylation. If INTS4's activity relates to genes modulated by DOT1L-mediated methylation, EPZ004777 can alter its function. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 stabilizes p53 by inhibiting MDM2. If INTS4's function or the Integrator complex is responsive to p53-mediated events, Nutlin-3 can influence INTS4's role. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid (VPA) is an HDAC inhibitor that can modulate gene transcription. This can lead to altered demands on the Integrator complex, thereby influencing INTS4. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is another DNA methyltransferase inhibitor. By affecting genes controlled by DNA methylation, it can indirectly modulate the function of INTS4 within the Integrator complex. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 inhibits G9a and GLP methyltransferases. If INTS4 activity relates to genes influenced by these methyltransferases, UNC0638 can affect its function. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is an HDAC inhibitor influencing gene transcription. Altered gene expression profiles can influence the demand on the Integrator complex, thus affecting INTS4. | ||||||