INTS2 Inhibitors
INTS2 inhibitors are chemical compounds that specifically target the INTS2 protein, a critical component of the Integrator complex. The Integrator complex is a multi-subunit assembly involved in the processing of small nuclear RNAs (snRNAs) and the regulation of gene transcription, particularly RNA polymerase II-dependent transcription. INTS2 plays a role in coordinating various subunits within this complex, ensuring the proper cleavage and maturation of snRNA, which are essential for the function of the spliceosome in pre-mRNA splicing. By inhibiting INTS2, these compounds interfere with the normal activity of the Integrator complex, leading to alterations in RNA processing and transcriptional regulation.
Mechanistically, INTS2 inhibitors work by binding to the INTS2 protein, preventing it from fulfilling its role within the Integrator complex. This disruption affects the processing of snRNAs, which in turn can lead to the improper assembly or function of the spliceosome and subsequent effects on mRNA splicing. The inhibition of INTS2 has downstream effects on gene expression, particularly in genes reliant on precise mRNA splicing and transcriptional control. These inhibitors are valuable tools in molecular biology and biochemistry research, as they allow scientists to dissect the functional roles of the Integrator complex and INTS2 in cellular processes. By using these inhibitors, researchers can explore the complex interplay between transcriptional regulation, RNA processing, and post-transcriptional modifications, thereby deepening our understanding of gene expression and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide interferes with the transcription of RNA by inhibiting the activity of RNA polymerase II. Since INTS2 is involved in RNA processing, triptolide's action can indirectly affect INTS2 function. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin binds strongly to RNA polymerase II and inhibits the elongation phase of RNA synthesis. As INTS2 has a role in RNA processing, inhibition of RNA polymerase II can impact INTS2 function indirectly. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II phosphorylation leading to the suppression of mRNA synthesis. This action can indirectly affect INTS2's role in RNA processing. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol inhibits cyclin-dependent kinases (CDKs) which are essential for the transcriptional regulation by phosphorylating the RNA polymerase II C-terminal domain. This can indirectly impact INTS2 function due to its involvement in RNA processing. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and prevents the transcription initiation by RNA polymerase, which could indirectly reduce INTS2 function since INTS2 is part of the integrator complex associated with transcription. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $341.00 $927.00 | 7 | |
ICRF-193 is a topoisomerase II inhibitor, and by preventing the relaxation of supercoiled DNA, it can indirectly affect transcription and consequently INTS2 function. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
WP1130 inhibits deubiquitinating enzymes, which can lead to the stabilization of proteins that regulate transcription factors and RNA processing, thereby indirectly affecting INTS2 function. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 selectively inhibits RNA polymerase I, thus affecting ribosomal RNA synthesis. This can indirectly affect INTS2 function due to its involvement in RNA processing. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is an adenosine analog that terminates RNA chain elongation by inhibiting RNA polymerase, thus affecting RNA processing in which INTS2 is involved. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, preventing the relegation of single-strand DNA breaks and indirectly affecting DNA transcription and INTS2 function in RNA processing. | ||||||