Integrin α10 Activators
Integrin α10 activators encompass a diverse range of chemical compounds that indirectly influence the activity of Integrin α10 through various cellular mechanisms. These activators operate primarily by modulating cell signaling pathways and cellular processes that are associated with integrin function. The mechanisms by which these chemicals act are intricate and multifaceted, reflecting the complex nature of integrin-mediated signaling and its role in cell adhesion and migration.
The primary mode of action of these chemicals involves the modulation of cellular signaling pathways that indirectly affect Integrin α10. For instance, compounds like EGF and Forskolin act by stimulating receptor pathways or increasing intracellular messenger levels, thereby influencing the integrin signaling cascade. Manganese (II) chloride and RGD Peptide, on the other hand, directly interact with integrins, inducing conformational changes that affect their ligand-binding properties. This modulation of integrin function is critical in regulating cellular processes such as adhesion, migration, and survival.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can affect integrin function. PKC activation can influence integrin clustering and cell adhesion properties. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can influence integrin-mediated signaling pathways, affecting cell adhesion and migration. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions can directly bind to integrins, inducing a conformational change that increases their affinity for ligands, potentially affecting integrin-mediated cell adhesion and signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophores increase intracellular calcium levels, which can affect integrin function. Calcium signaling is crucial for the regulation of integrin-mediated cell adhesion. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Nitric oxide can modulate integrin function. It influences cell adhesion and migration by affecting the cytoskeleton and integrin signaling. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin can influence integrin activation, particularly in platelets. It affects cell adhesion and signaling pathways related to integrin function. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA affects integrin signaling through G-protein-coupled receptors. It influences cell adhesion, migration, and survival. | ||||||
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Collagen is a natural ligand for several integrins. Its interaction with integrins initiates signaling cascades that influence cell adhesion and migration. | ||||||
Fibronectin | sc-29011 sc-29011A | 1 mg 5 mg | $143.00 $504.00 | 94 | ||
Fibronectin binds to integrins, influencing their activation and downstream signaling pathways related to cell adhesion and migration. | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $208.00 | ||
Hyaluronic acid interacts with cell surface receptors, potentially affecting integrin function and influencing cell adhesion and migration. | ||||||