INPP5J Activators
INPP5J activators pertain to a chemical class that targets the enzyme INPP5J, also known as Inositol Polyphosphate-5-Phosphatase J. This enzyme is part of a larger family of phosphatases that play a critical role in the regulation of cellular processes by modulating the phosphoinositide signaling pathway. Phosphoinositides are a group of membrane lipids that are phosphorylated derivatives of phosphatidylinositol, and they are critical for various cellular functions, including membrane trafficking, cytoskeletal organization, and signal transduction. INPP5J selectively dephosphorylates the 5' position of the inositol ring of inositol polyphosphate substrates, converting phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) into phosphatidylinositol 4-phosphate (PI4P), and thus, it plays a pivotal role in the regulation of the cellular levels of these signaling molecules.
Activators of INPP5J are compounds that enhance the activity of the INPP5J enzyme. By increasing the enzyme's activity, these activators can shift the balance of cellular phosphoinositides. The precise mechanism by which INPP5J activators exert their effect on the enzyme may vary; some might bind to the enzyme and induce a conformational change that results in higher catalytic activity, while others could interact with regulatory domains or binding partners that modulate the enzyme's function. The significance of INPP5J and its activators lies in their ability to influence the dynamics of phosphoinositide pools within the cell, which in turn can affect a multitude of signaling pathways and cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, through its modulation of sirtuins, can affect phosphoinositide signaling, potentially amplifying INPP5J's phosphatase activity by modifying its substrate availability. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA, by modulating phospholipid composition and related cellular signaling, can influence INPP5J by altering its lipid substrate profile. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
By inhibiting tyrosine kinases, Genistein may shift cellular signaling balances, leading to an environment where INPP5J activity is favored. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels. Elevated cAMP can modify phosphoinositide signaling dynamics, potentially favoring INPP5J phosphatase activity. | ||||||
C-8 Ceramide | 74713-59-0 | sc-205233 sc-205233A sc-205233B | 1 mg 5 mg 25 mg | $19.00 $63.00 $228.00 | 1 | |
Ceramide's role in sphingolipid signaling can interact with phosphoinositide pools, potentially influencing INPP5J's phosphatase function by altering substrate availability. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
By modulating eicosanoid signaling and membrane phospholipid dynamics, Arachidonic acid can modify the lipid substrates accessible for INPP5J, potentially enhancing its activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
As an antioxidant, Alpha-lipoic acid can alter redox-sensitive cellular signaling, which might impact phosphoinositide dynamics and favor INPP5J activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
By acting as a redox signaling molecule, Hydrogen peroxide can influence phosphoinositide-based signaling cascades, potentially favoring INPP5J's phosphatase role. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine's ability to elevate cAMP levels can modify phosphoinositide signaling dynamics, which might create an environment where INPP5J activity is favored. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, through its broad cellular signaling modulation, might influence phosphoinositide pools in a manner that amplifies INPP5J's phosphatase function. | ||||||