Ini1 Activators
Ini1 Activators are a class of chemical compounds that are associated with the modulation or enhancement of the biological activity of Ini1, also known as SMARCB1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1). Ini1 is a crucial component of the SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex, which plays a pivotal role in the regulation of gene expression and chromatin structure. This complex is responsible for altering the accessibility of DNA to transcription factors and other regulatory proteins by using the energy from ATP hydrolysis to reposition, eject, or modify nucleosomes. Ini1 itself acts as a scaffold within the SWI/SNF complex and helps maintain the structural integrity and functionality of this essential chromatin remodeling machinery.
Ini1 Activators are believed to interact with Ini1, influencing its conformation, binding affinities for other components of the SWI/SNF complex, or its ability to remodel chromatin. By targeting Ini1, these activators can modulate the activity of the SWI/SNF complex, which, in turn, can impact the transcriptional regulation of genes involved in various cellular processes. The SWI/SNF complex has been implicated in diverse biological functions, including cell differentiation, cell cycle control, and DNA repair. Moreover, alterations in Ini1 expression or function are associated with certain cancers and developmental disorders, highlighting the significance of understanding Ini1 Activators and their role in controlling chromatin dynamics and gene expression. Research in this area contributes to our knowledge of epigenetic regulation and gene expression control mechanisms within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a DNA methyltransferase inhibitor, potentially inducing Ini1 expression by demethylating DNA and thereby activating previously silenced genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a short-chain fatty acid, Sodium Butyrate acts as a histone deacetylase inhibitor, potentially enhancing Ini1 expression through epigenetic modifications. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, also a histone deacetylase inhibitor, may modulate Ini1 expression by altering the histone acetylation status and thereby influencing gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, a metabolite of Vitamin A, might induce Ini1 expression by binding to retinoic acid receptors and modulating gene expression patterns. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
This compound may influence Ini1 expression by modulating Wnt signaling pathways, which are crucial for gene expression regulation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and may alter the expression of Ini1 by interfering with specific transcription factor binding sites. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, may affect Ini1 expression indirectly by altering the degradation of proteins involved in transcriptional regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may modulate Ini1 expression through its effects on various signaling pathways, including NF-κB, which plays a role in gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Found in green tea, this compound may influence Ini1 expression by affecting signaling pathways and epigenetic mechanisms involved in gene regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural phenol, might induce Ini1 expression through its impact on sirtuin pathways and chromatin remodeling processes. | ||||||