INF2 Inhibitors
INF2 pivotal role in various cellular processes, particularly those related to cytoskeletal dynamics and membrane remodeling. INF2 is recognized for its involvement in the regulation of actin polymerization and microtubule dynamics, processes essential for maintaining cell shape, intracellular transport, and overall cellular architecture. INF2 inhibitors specifically target its enzymatic activity, which is primarily linked to the modulation of actin dynamics.
By inhibiting INF2, these compounds are thought to impact the cytoskeleton's organization and stability, thereby potentially influencing various cellular functions. The chemical structures of these inhibitors interact with specific binding sites on INF2, disrupting its normal enzymatic function. Through these mechanisms, INF2 inhibitors offer researchers valuable tools for investigating the intricate details of cytoskeletal dynamics and their roles in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 inhibits INF2 by disrupting its interaction with actin filaments, leading to impaired actin dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the barbed end of actin filaments, preventing polymerization and INF2 activation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin B sequesters G-actin, reducing the availability of monomers for INF2-mediated actin polymerization. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 targets the Arp2/3 complex, an INF2 cofactor, inhibiting its nucleation of new actin filaments. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $160.00 | ||
CK-869 impedes INF2-induced actin filament elongation by targeting the barbed end and preventing subunit addition. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A stabilizes actin filaments in a state that is refractory to INF2-mediated actin remodeling. | ||||||
CK-689 | 170930-46-8 | sc-507371 | 25 mg | $312.00 | ||
CK-689 disrupts the INF2-Arp2/3 interaction, impairing the recruitment of Arp2/3 complex to growing actin filaments. | ||||||