IL-5 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
YM 90709 | 163769-88-8 | sc-361414 | 10 mg | $189.00 | ||
YM 90709 functions as an IL-5 antagonist, showcasing a distinctive mechanism of action through its selective binding to the IL-5 receptor. This interaction alters the receptor's conformation, preventing the activation of downstream signaling cascades associated with eosinophil proliferation. The compound exhibits a unique affinity profile, with a notable rate of association that enhances its effectiveness in modulating immune responses. Its behavior underscores the intricate balance of cytokine signaling in immune regulation. | ||||||
Budesonide | 51333-22-3 | sc-202980 sc-202980A sc-202980B sc-202980C | 50 mg 100 mg 200 mg 500 mg | $77.00 $88.00 $151.00 $343.00 | 3 | |
Budesonide inhibits NF-κB signaling, specifically impacting the transcription factor GATA3. GATA3 is crucial for IL-5 gene expression, and by targeting this transcription factor, Budesonide indirectly modulates IL-5 expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580, a p38 MAPK inhibitor, influences the MAPK pathway. By inhibiting p38 MAPK, it disrupts the downstream signaling cascades involving IL-5, leading to indirect modulation of IL-5 expression. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol inhibits cyclin-dependent kinases, including CDK9. As CDK9 is involved in RNA polymerase II transcription, Flavopiridol indirectly modulates IL-5 expression by inhibiting transcription elongation and RNA synthesis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, impacting the PI3K/Akt pathway. By disrupting this pathway, Wortmannin indirectly modulates IL-5 expression, as PI3K signaling plays a role in the regulation of IL-5 production. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, affecting the NFAT pathway. NFAT is involved in IL-5 gene expression, and by targeting calcineurin, Cyclosporin A indirectly modulates IL-5 expression through the inhibition of NFAT-mediated transcription. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that impacts the PI3K/Akt pathway. By inhibiting PI3K, it disrupts signaling events crucial for IL-5 production, leading to the indirect modulation of IL-5 expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits NF-κB activation and downstream gene expression. Through this mechanism, it indirectly modulates IL-5 expression by disrupting the NF-κB signaling pathway, which is implicated in the regulation of IL-5. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 inhibits JNK, influencing the MAPK pathway. By targeting JNK, this compound indirectly modulates IL-5 expression by disrupting the MAPK-dependent signaling events involved in IL-5 regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, impacting the PI3K/Akt/mTOR pathway. By disrupting this pathway, Rapamycin indirectly modulates IL-5 expression, as mTOR is implicated in the regulation of IL-5 production. | ||||||