IL-3R Activators
Interleukin-3 Receptor (IL-3R) is a crucial component of the hematopoietic system and plays a pivotal role in the maintenance and development of various blood cells. This receptor is a transmembrane protein consisting of two subunits; the alpha (IL-3Rα) and beta (IL-3Rβ) chains. The alpha chain is specific to IL-3R, binding the cytokine IL-3 with high affinity, while the beta chain is shared among receptors for other cytokines, contributing to a broader signaling capacity. The activation of IL-3R by its ligand, IL-3, initiates a cascade of intracellular events leading to diverse biological outcomes, including cell survival, proliferation, and differentiation. The expression of IL-3R is tightly regulated, reflecting its significance in the controlled production and function of blood cells. Changes in the expression of IL-3R can influence the behavior of cells and are of interest in understanding the mechanisms governing hematopoiesis and immune responses.
Research into the regulation of IL-3R expression has identified various chemical compounds that can potentially serve as activators, each interacting with unique cellular pathways. Retinoic acid, for example, is known to stimulate gene transcription through its interaction with retinoic acid receptors, which may include genes encoding for the IL-3R subunits. Vitamin D3, through its hormone-active form, can bind to cellular receptors and potentially stimulate the transcription of immune-related genes, including those related to IL-3R. Compounds like Forskolin and Phorbol 12-myristate 13-acetate (PMA) are known to activate adenylate cyclase and protein kinase C, respectively, both of which can lead to increased transcription of certain genes. This is thought to potentially include genes related to IL-3R expression. Furthermore, compounds such as Sodium butyrate and Sulforaphane, which influence the epigenetic landscape of cells, may also play a role in the upregulation of IL-3R. These compounds act on the chromatin structure and transcription factors, possibly leading to an increase in the expression of genes involved in immune function. Although the potential for these chemicals to serve as activators of IL-3R expression is based on their known biological activities, the actual impact on IL-3R requires careful experimental investigation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can initiate transcription of certain genes by binding to retinoic acid receptors. This binding may upregulate IL-3R expression as part of cellular differentiation in hematopoietic cells. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
The active form of Cholecalciferol can stimulate vitamin D receptors, potentially leading to the transcription of genes including those associated with immune function, possibly stimulating IL-3R expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can activate glucocorticoid receptors, potentially triggering a cascade of gene transcription events that may include the upregulation of IL-3R expression in immune cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can activate protein kinase C, potentially initiating a signaling cascade that stimulates the transcription of genes, including possibly those coding for IL-3R. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium may upregulate IL-3R expression by inhibiting GSK-3, a kinase involved in multiple signaling pathways, potentially leading to changes in gene transcription relevant to immune response. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate can inhibit histone deacetylases, potentially leading to a relaxed chromatin structure and the subsequent transcriptional upregulation of certain genes, such as IL-3R. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase activity, increasing cAMP levels, which might lead to the activation of CREB and the subsequent transcriptional increase of IL-3R expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can stimulate the SIRT1 pathway, which may lead to the deacetylation of transcription factors and the potential upregulation of IL-3R gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate, through its antioxidant properties, may stimulate the Nrf2 pathway, potentially leading to an increase in the transcription of antioxidant response genes, including potentially IL-3R. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin can trigger the activation of the p38 MAPK pathway, which may lead to the stimulation of gene transcription and potentially elevate IL-3R expression levels. | ||||||