IL-18BP Activators
IL-18BP, or interleukin-18 binding protein, is a naturally occurring inhibitor of the pro-inflammatory cytokine interleukin-18 (IL-18). This protein plays a crucial role in modulating the immune response by binding to IL-18, thereby preventing its interaction with the IL-18 receptor and subsequent activation of inflammatory pathways. The action of IL-18BP is pivotal in maintaining the balance between pro- and anti-inflammatory signals within the body, ensuring that immune responses are appropriately regulated to protect the host while minimizing potential damage to tissues from excessive inflammation. The function of IL-18BP is particularly important in conditions characterized by chronic inflammation, where its ability to neutralize IL-18 can help to prevent tissue damage and the progression of inflammatory diseases. By inhibiting the activity of IL-18, IL-18BP contributes to the control of cytokine release syndrome and the modulation of immune responses against infections, autoimmunity, and other pathological conditions.
The activation of IL-18BP, in terms of its expression and functional upregulation, is primarily regulated at the genetic level, influenced by various signaling molecules and transcription factors responsive to inflammatory signals and immune activation. Key regulators include interferons (IFNs), particularly IFN-γ, which can significantly upregulate the expression of IL-18BP. This upregulation serves as a feedback mechanism to control the effects of IL-18, especially during Th1-type immune responses where IFN-γ and IL-18 are prominently produced. The synthesis and release of IL-18BP are thus tightly integrated with the immune response, ensuring a timely counteraction against excessive IL-18-mediated activities. Furthermore, other cytokines and growth factors can modulate the expression of IL-18BP, adapting its levels to the current immunological context and maintaining homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $811.00 | ||
Anakinra is an IL-1 receptor antagonist that can indirectly influence IL-18BP by modulating IL-1 related pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can inhibit NF-κB, which indirectly affects IL-18 transcription and hence can influence IL-18BP. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate the NF-κB pathway, impacting the IL-18 expression and consequently IL-18BP. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can inhibit NF-κB and modulate cytokine production, potentially influencing IL-18 and IL-18BP. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can suppress the NF-κB pathway and can influence IL-18 expression and its binding protein, IL-18BP. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can modulate several signaling pathways including NF-κB, indirectly influencing IL-18 and IL-18BP. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC can regulate oxidative stress and modulate NF-κB, affecting IL-18 and its binding protein. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin can suppress the NF-κB pathway, influencing the expression of IL-18 and consequently IL-18BP. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine can modulate the NF-κB pathway and can therefore influence IL-18 and IL-18BP. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide can inhibit NF-κB and can thus influence the IL-18 pathway and IL-18BP. | ||||||