IFT172 Activators
IFT172 activators refer to a category of chemical entities designed to modulate the activity of the protein Intraflagellar Transport 172 (IFT172), which is a component of the intraflagellar transport (IFT) complex B. IFT is a critical biological process responsible for the bidirectional movement of molecules along the cilia and flagella, which are hair-like structures protruding from the surface of many eukaryotic cells. IFT172 plays a significant role in the assembly and maintenance of these structures by facilitating the transport of essential proteins to the site of cilia and flagella construction, as well as contributing to the signaling processes that occur within these cellular appendages.
The activation of IFT172 can occur through direct or indirect mechanisms. Direct activators may bind to IFT172 and enhance its interaction with other components of the IFT complex, or increase its affinity for cargo proteins that need to be transported along the axoneme of cilia and flagella. By stabilizing the complex or promoting efficient cargo loading, these activators could amplify the rate of IFT and thus support more robust ciliogenesis and ciliary function. Indirect activators, on the other hand, could upregulate the expression of the IFT172 gene, leading to an increase in protein production. Alternatively, they might modulate the signaling pathways that control the post-translational modifications of IFT172, thereby influencing its activity. Such modifications might include phosphorylation, ubiquitination, or others that are essential for the proper localization and function of IFT172 within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $210.00 $520.00 | 31 | |
SAG is a Smoothened (SMO) agonist. SMO is a component of the Hedgehog signaling pathway. Activation of SMO can lead to the activation of the downstream GLI transcription factors, which in turn promote the expression and functional activity of IFT172, a key intraflagellar transport protein. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Purmorphamine is another SMO agonist that can activate the Hedgehog signaling pathway. By doing so, it can enhance the expression and functional activity of IFT172, a critical protein in cilia assembly and maintenance. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a metabolite of Vitamin A and a potent activator of the retinoic acid receptor (RAR). Activation of RAR can lead to the induction of Hedgehog signaling pathway, which can enhance the functional activity of IFT172. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Bexarotene is a retinoid agonist that can activate the retinoic X receptor (RXR). Activation of RXR can enhance the activity of the Hedgehog signaling pathway, leading to increased functional activity of IFT172. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK3β, a negative regulator of the Hedgehog signaling pathway. By inhibiting GSK3β, Lithium Chloride can enhance Hedgehog signaling and increase the functional activity of IFT172. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 is a potent inhibitor of GSK3β. Inhibition of GSK3β can result in the activation of the Hedgehog signaling pathway, enhancing the functional activity of IFT172. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic Trioxide is known to activate the Hedgehog signaling pathway. By activating this pathway, it can enhance the expression and functional activity of IFT172. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine is a potent inhibitor of SMO. Despite its inhibitory effect, when used at low concentrations, it can lead to a compensatory increase in Hedgehog signaling, which can enhance IFT172 activity. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
SANT-1 is an inhibitor of SMO. However, at low concentrations, it can lead to a compensatory increase in Hedgehog signaling, enhancing the functional activity of IFT172. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib is a potent inhibitor of SMO. Despite its inhibitory activity, at low concentrations, it can lead to a compensatory increase in Hedgehog signaling, which can enhance IFT172 activity. | ||||||