IFITM1 Inhibitors
IFITM1 inhibitors belong to a class of chemical compounds designed to modulate the activity of Interferon-Induced Transmembrane Protein 1 (IFITM1). IFITM1 is a crucial component of the innate immune system, known for its role in inhibiting the entry of a wide range of viruses, including influenza, HIV, and SARS-CoV-2, into host cells. IFITM1 is a transmembrane protein localized in the cellular membrane compartments, such as endosomes, lysosomes, and the plasma membrane, where it exerts its antiviral effects by interfering with viral fusion and entry. IFITM1 inhibitors aim to disrupt or attenuate the function of IFITM1, thereby rendering host cells more susceptible to viral infections.
Chemically, IFITM1 inhibitors can take various forms, such as small molecules or peptides, that are designed to interact with IFITM1 either directly or indirectly. These inhibitors are engineered to modulate the protein's activity without compromising the overall function of the host cell. By inhibiting IFITM1, these compounds may provide insights into the mechanism of viral entry and leads to the development of novel strategies for managing viral infections. While the development and study of IFITM1 inhibitors are still ongoing, they hold promise as a valuable tool in advancing our understanding of host-virus interactions and may have implications in the field of antiviral research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound incorporates into DNA and inhibits DNA methyltransferase, potentially leading to demethylation of IFITM1 promoter and reduced expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it alters chromatin structure and can suppress IFITM1 gene transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine inhibits DNA methylation, which could lead to decreased IFITM1 expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
It is a non-nucleoside inhibitor of DNA methyltransferase, potentially resulting in reduced methylation of IFITM1 promoter. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $108.00 $336.00 | 9 | |
As a histone deacetylase inhibitor, it can modify chromatin structure and potentially suppress IFITM1 transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Known to modulate various signaling pathways, it has the potential to downregulate IFITM1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
It can modulate signaling pathways, possibly leading to reduced IFITM1 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
This compound is known to activate antioxidant response elements, potentially leading to decreased IFITM1 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A major component of green tea, EGCG has potential anti-inflammatory effects and may downregulate IFITM1 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Known to modulate immune responses, it has the potential to alter IFITM1 expression levels. | ||||||