Iba1 Inhibitors
Common Iba1 Inhibitors include, but are not limited to Minocycline, Hydrochloride CAS 13614-98-7, Nimesulide CAS 51803-78-2, Resveratrol CAS 501-36-0, Piceatannol CAS 10083-24-6 and Baicalein CAS 491-67-8.
Ionized calcium-binding adapter molecule 1 (Iba1) is a protein primarily recognized for its pivotal role in the immune response processes within the central nervous system (CNS). Found abundantly in microglia, the primary immune cells of the CNS, Iba1 acts as a modulator of membrane ruffling and phagocytosis. These specific functions enable microglia to detect, respond to, and mitigate various forms of neural injuries or anomalies. Due to its integral role, Iba1 is often employed as a marker to identify and study activated microglia in various neuropathological conditions.
Iba1 inhibitors are a class of chemical entities designed to specifically target and modulate the activity of the Iba1 protein. Their primary aim is to regulate or reduce the functions of Iba1, thereby influencing the activities of microglia. These inhibitors can function through multiple mechanisms: some may interact directly with the Iba1 protein, inhibiting its natural activities, while others might target associated pathways or proteins that influence Iba1's expression or function. The intricate mechanisms by which these compounds work underscore the complexity of microglial activation and its broader implications in the CNS.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Minocycline, Hydrochloride | 13614-98-7 | sc-203339 sc-203339A sc-203339B sc-203339C sc-203339D sc-203339E sc-203339F | 50 mg 250 mg 1 g 2.5 g 10 g 100 g 1 kg | $52.00 $168.00 $275.00 $622.00 $1234.00 $5722.00 $24490.00 | 36 | |
Minocycline is a tetracycline antibiotic known to suppress microglial activation. It may reduce Iba1 expression by inhibiting microglial activity. | ||||||
Nimesulide | 51803-78-2 | sc-200623 | 5 g | $71.00 | 1 | |
This NSAID has shown potential in reducing microglial activation. By inhibiting microglial activity, nimesulide might suppress Iba1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can modulate inflammatory responses. It may downregulate Iba1 by suppressing microglial activation. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol is known to inhibit inflammatory pathways in microglia. Its anti-inflammatory effects may lead to reduced Iba1 expression. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein is a flavonoid with anti-inflammatory properties that may suppress microglial activation, potentially leading to decreased Iba1 expression. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $104.00 $204.00 | 6 | |
This NSAID might reduce Iba1 expression by suppressing the inflammatory responses in microglia. | ||||||
Nefiracetam | 77191-36-7 | sc-205766 sc-205766A | 100 mg 250 mg | $128.00 $143.00 | 1 | |
Nefiracetam has demonstrated neuroprotective effects, potentially by reducing microglial activation and thereby Iba1 expression. | ||||||
Artesunate | 88495-63-0 | sc-201329 sc-201329A | 10 mg 50 mg | $61.00 $282.00 | 5 | |
Artesunate has anti-inflammatory properties and may inhibit Iba1 expression by reducing microglial activation. | ||||||
Ginsenoside Rg1 | 22427-39-0 | sc-205708 sc-205708A | 5 mg 10 mg | $260.00 $476.00 | ||
Ginsenoside Rg1, a component of ginseng, may exert neuroprotective effects by suppressing microglial activation, leading to decreased Iba1 expression. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
As a PPAR-γ agonist, pioglitazone might reduce microglial activation and consequently downregulate Iba1 expression. | ||||||