Molecular structure of Nimesulide, CAS Number: 51803-78-2
Nimesulide (CAS 51803-78-2)
See product citations (1)
Alternate Names:
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Application:
Nimesulide is a selective Cox-2 inhibitor
CAS Number:
51803-78-2
Purity:
>99%
Molecular Weight:
308.3
Molecular Formula:
C13H12N2O5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Nimesulide is an anti-inflammatory small molecule inhibitor of Cox (cyclooxygenase). Nimesulide shows selectivity for Cox-2 over Cox-1. Reports have suggested that increased Cox-2 expression may present a survival advantage to cells by inhibiting apoptosis and changing cellular adhesions to the extracellular matrix, and Nimesulide is demonstrated to suppress azoxymethane-induced carcinogenesis.
Nimesulide (CAS 51803-78-2) References
- Molecular model of the interaction between nimesulide and human cyclooxygenase-2. | García-Nieto, R., et al. 1999. Rheumatology (Oxford). 38 Suppl 1: 14-8. PMID: 10369401
- The in vivo assessment of nimesulide cyclooxygenase-2 selectivity. | Shah, AA., et al. 1999. Rheumatology (Oxford). 38 Suppl 1: 19-23. PMID: 10369402
- Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug. | Suleyman, H., et al. 2008. Curr Med Chem. 15: 278-83. PMID: 18333314
- Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4. | Yang, S., et al. 2012. Indian J Pharmacol. 44: 599-601. PMID: 23112421
- Pharmacokinetic variations of nimesulide in mongrel dogs according to age. | Guillé, PG., et al. 2019. Pharmazie. 74: 728-731. PMID: 31907111
- In vivo antidiabetic activity of nimesulide due to inhibition of amino acid transport. | Joharapurkar, A., et al. 2022. Basic Clin Pharmacol Toxicol. 130: 35-43. PMID: 34634192
- Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †. | Vunnam, N., et al. 2023. Cancer Biol Ther. 24: 2176692. PMID: 36775838
- Nimesulide as a downregulator of the activity of the neutrophil myeloperoxidase pathway. Focus on the histoprotective potential of the drug during inflammatory processes. | Ottonello, L., et al. 1993. Drugs. 46 Suppl 1: 29-33. PMID: 7506191
- Recent contributions to knowledge of the mechanism of action of nimesulide. | Bevilacqua, M. and Magni, E. 1993. Drugs. 46 Suppl 1: 40-7. PMID: 7506193
- Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. | Tsujii, M. and DuBois, RN. 1995. Cell. 83: 493-501. PMID: 8521479
- Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. | Okajima, E., et al. 1998. Cancer Res. 58: 3028-31. PMID: 9679967
- Experimental models used to investigate the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 by non-steroidal anti-inflammatory drugs. | Pairet, M. and van Ryn, J. 1998. Inflamm Res. 47 Suppl 2: S93-101. PMID: 9831330
- Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice. | Fukutake, M., et al. 1998. Carcinogenesis. 19: 1939-42. PMID: 9855006
Inhibitor of:
AKR1C12, AKR1C18, AKR1C6, Cox-2, group IVC sPLA2, Iba1, LPLUNC3, and OPN1LW.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nimesulide, 5 g | sc-200623 | 5 g | $71.00 |