IAH1 Inhibitors
Wortmannin and LY294002 both inhibit phosphatidylinositol 3-kinases (PI3K), which are involved in a multitude of signaling pathways that regulate functions such as cell growth, proliferation, and survival. Triciribine is an Akt inhibitor, and since Akt is a downstream effector of PI3K, this compound could also impact any processes that IAH1 may influence downstream of PI3K signaling.
The chemical class of IAH1 Inhibitors would be composed of molecules that specifically interact with the IAH1 protein to modify its activity. These inhibitors would be structured to engage with the active or allosteric sites on IAH1, or they might interact with regulatory domains that control the protein's function. Their design would be based on the detailed knowledge of IAH1's structure and the cellular context of its action. High-throughput screening techniques would be employed to discover initial candidates, followed by iterative cycles of medicinal chemistry to enhance the specificity and potency of these inhibitors.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibits PI3K, which may impact signaling cascades that IAH1 is a part of by altering phosphorylation states. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Targets Akt, potentially modifying downstream signaling that could intersect with IAH1's function. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
FGFR inhibitor that can disrupt growth factor signaling, potentially influencing pathways that IAH1 regulates. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Inhibits Raf kinase, which could alter MAPK/ERK pathway activity and affect IAH1's role in signal transduction. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Inhibits cyclin-dependent kinases (CDKs), potentially impacting cell cycle regulation involving IAH1. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits TGF-β receptor kinase, potentially affecting TGF-β signaling pathways where IAH1 might be implicated. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Inhibits AMPK, which could affect cellular energy homeostasis and pathways regulated by IAH1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK, potentially affecting cytoskeletal organization and functions that may involve IAH1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which may affect various signaling pathways, possibly interacting with IAH1's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, potentially affecting stress response pathways that IAH1 may be part of. | ||||||