HtrA2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Omi/HtrA2 Protease Inhibitor, Ucf-101 | 313649-08-0 | sc-222101 | 10 mg | $200.00 | 1 | |
Ucf-101, an Omi/HtrA2 protease inhibitor, selectively binds to the active site of the HtrA2 protein, disrupting its proteolytic activity. This interaction alters the conformational dynamics of HtrA2, influencing its role in mitochondrial stress responses. The compound exhibits unique reaction kinetics, characterized by a rapid association and slower dissociation, which enhances its inhibitory effect. Its hydrophobic regions facilitate membrane interactions, impacting cellular localization and function. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Tetracycline antibiotic; binds to the 30S ribosomal subunit, inhibiting protein synthesis. HtrA proteins are involved in protein quality control, and their inhibition can occur indirectly by reducing the overall burden of misfolded proteins. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
A cell-permeable, irreversible inhibitor of cysteine proteases; could reduce the burden on HtrA proteases by limiting substrate availability. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Serine protease inhibitor; while primarily targeting other proteases, it can indirectly reduce proteolytic stress on cellular mechanisms where HtrA is involved. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $153.00 $255.00 $627.00 $1163.00 $2225.00 | 3 | |
Inhibitor of chymotrypsin-like proteases; can also decrease the overall protease load and indirectly reduce HtrA activity by reducing protein misfolding and aggregation. | ||||||
PD 151746 | 179461-52-0 | sc-222134 | 5 mg | $192.00 | 3 | |
Calpain inhibitor; indirectly affects protease pathways and could reduce the proteolytic processing within cells, possibly affecting HtrA activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor; by blocking proteasomal degradation, it could lead to a reduced need for HtrA activity as misfolded proteins accumulate. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A catechin found in green tea; known to modulate various signaling pathways and protease activities, potentially impacting HtrA function indirectly. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
PPARγ agonist; alters gene expression and may influence proteostasis, thereby indirectly affecting HtrA function. | ||||||