Molecular structure of PD 151746, CAS Number: 179461-52-0
PD 151746 (CAS 179461-52-0)
See product citations (3)
Alternate Names:
3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
Application:
PD 151746 is a selective non-peptidic calpain inhibitor
CAS Number:
179461-52-0
Purity:
≥95%
Molecular Weight:
237.3
Molecular Formula:
C11H8FNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD 151746 is a cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the Ca2+ binding sites of calpain. PD 151746 exhibits greater selectivity over calpain-1 than calpain-2. PD 151746 has also been shown to prevent cycloheximide-induced apoptosis.
PD 151746 (CAS 179461-52-0) References
- Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. | Pörn-Ares, MI., et al. 2003. Biochem J. 374: 403-11. PMID: 12775216
- The beta3-adrenergic agonist CL316,243 inhibits insulin signaling but not glucose uptake in primary human adipocytes. | Jost, MM., et al. 2005. Exp Clin Endocrinol Diabetes. 113: 418-22. PMID: 16151974
- Calpain inhibition impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling. | Meier, M., et al. 2007. J Endocrinol. 193: 45-51. PMID: 17400802
- Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation. | Fujita, H., et al. 2011. Arch Biochem Biophys. 516: 121-7. PMID: 22005393
- Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. | Lei, H., et al. 2017. PLoS One. 12: e0169788. PMID: 28060905
- Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling. | Wu, X., et al. 2018. Brain Res Bull. 139: 133-143. PMID: 29477834
- Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain. | Zhang, ZQ., et al. 2024. CNS Neurosci Ther. 30: e14365. PMID: 37485782
- An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. | Wang, KK., et al. 1996. Proc Natl Acad Sci U S A. 93: 6687-92. PMID: 8692879
- Calpain and calpastatin regulate neutrophil apoptosis. | Squier, MK., et al. 1999. J Cell Physiol. 178: 311-9. PMID: 9989777
Inhibitor of:
Apoptosis, Calpain 1, Calpain 2, CAP2, cystatin E/M, and HtrA2.Activator of:
Calpain II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 151746, 5 mg | sc-222134 | 5 mg | $192.00 |