HSPA12B Activators
HSPA12B activators are a class of chemicals that can potentially influence the expression of the heat shock protein HSPA12B. These chemicals primarily work through disrupting protein homeostasis and inducing the heat shock response.
Activators of this class inhibit heat shock proteins such as Hsp90 or Hsp70. Inhibition of these proteins can induce the heat shock response, leading to increased expression of other heat shock proteins, including HSPA12B. Other activaotrs of this class are proteasome inhibitors. Inhibition of the proteasome can lead to an accumulation of misfolded proteins, inducing the heat shock response and potentially increasing HSPA12B expression. Finally, activators that disrupt proteostasis and induce the heat shock response also belong to this class.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is a Hsp90 inhibitor, which can induce the expression of other heat shock proteins, including HSPA12B, as part of the cellular response to protein misfolding. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol is another Hsp90 inhibitor, which can induce the expression of HSPA12B as part of the heat shock response. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is a derivative of geldanamycin that inhibits Hsp90, potentially leading to increased expression of HSPA12B. | ||||||
17-DMAG | 467214-20-6 | sc-202005 | 1 mg | $205.00 | 8 | |
17-DMAG is another derivative of geldanamycin that inhibits Hsp90, potentially leading to increased expression of HSPA12B. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor, which can lead to accumulation of misfolded proteins and activation of the heat shock response, including increased expression of HSPA12B. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor that can induce the heat shock response and increase HSPA12B expression. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
Carfilzomib is a proteasome inhibitor that can activate the heat shock response, potentially leading to increased HSPA12B expression. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a proteasome inhibitor that can induce the heat shock response, potentially leading to increased HSPA12B expression. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a natural compound that disrupts proteostasis and induces the heat shock response, potentially leading to increased HSPA12B expression. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a steroidal lactone that can disrupt proteostasis and induce the heat shock response, potentially leading to increased HSPA12B expression. | ||||||