HSPA12B Antibody (C-4): sc-393635

HSPA12B Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSPA12B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-HSPA12B antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSPA12B, also known as heat shock 70 kDa protein 12B, is a 686 amino acid protein that plays a crucial role in cellular stress responses, particularly in endothelial cells of muscle and heart tissues, as well as in the liver and kidney. One of the significant aspects of HSPA12B is its involvement in post-translational modifications, particularly phosphorylation, which can influence chaperone activity and stability. These modifications are essential for regulating HSPA12B function in response to stress, as they can alter interactions with client proteins and other molecular chaperones, thereby impacting processes such as protein folding and degradation. HSPA12B is believed to be involved in angiogenesis and stress signaling related to wound healing, and upregulation in atherosclerotic lesions suggests a protective role against atherosclerotic damage. HSPA12B monoclonal antibody (C-4) enables valuable insights into HSPA12B function and implications in various physiological and pathological processes.

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HSPA12B Antibody (C-4) References:

1. Two Hsp70 family members expressed in atherosclerotic lesions.  |  Han, Z., et al. 2003. Proc Natl Acad Sci U S A. 100: 1256-61. PMID: 12552099
2. HSPA12B is predominantly expressed in endothelial cells and required for angiogenesis.  |  Steagall, RJ., et al. 2006. Arterioscler Thromb Vasc Biol. 26: 2012-8. PMID: 16825593
3. A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro.  |  Hu, G., et al. 2006. J Cell Sci. 119: 4117-26. PMID: 16968741
4. HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease.  |  Howarth, JL., et al. 2009. J Neurochem. 108: 945-951. PMID: 19183265
5. Induction of overexpression of the 27- and 70-kDa heat shock proteins by bicyclol attenuates concanavalin A-Induced liver injury through suppression of nuclear factor-kappaB in mice.  |  Bao, XQ. and Liu, GT. 2009. Mol Pharmacol. 75: 1180-8. PMID: 19188336

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSPA12B Antibody (C-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HSPA12B Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSPA12B Antibody (C-4) Specifications

Alternate Product Name: HSPA12B

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-63

Epitope Target: HSPA12B

Epitope Species: human

Product Reactivity/Detection: HSPA12B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HSPA12B Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin