HS3ST4 Activators
HS3ST4 activators are an ensemble of chemicals that, whether directly or indirectly, impact the function or expression of HS3ST4, an enzyme vital in heparan sulfate modification. Understanding these activators necessitates an appreciation for the complexities of heparan sulfate biosynthesis and the broader cellular landscape. Growth factors like EGF play instrumental roles in cell growth, differentiation, and tissue repair, and their involvement in heparan sulfate biology suggests they can modulate HS3ST4 activity. Indeed, these factors intertwine with the heparan sulfate landscape, fine-tuning HS3ST4's enzymatic operations.
The influence of signaling modulators on HS3ST4 offers insights into the broader cellular context in which this enzyme operates. Chemicals like Forskolin and PMA, which modulate cAMP levels and activate PKC, respectively, highlight the interconnected nature of cellular pathways. Their ability to influence a myriad of cellular events implies an indirect modulation of HS3ST4 activity. Furthermore, compounds such as LY-294,002 and U0126, which inhibit key components of vital signaling pathways like PI3K and MAPK/ERK, provide avenues through which HS3ST4 activity can be adjusted.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium chlorate | 7775-09-9 | sc-212938 | 100 g | $58.00 | 1 | |
As an inhibitor of sulfation, its presence might increase HS3ST4 activity as a compensatory mechanism. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PKC activator; PKC can affect multiple cellular processes including glycosaminoglycan biosynthesis which HS3ST4 is involved in. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
By modulating calcium levels, it can influence cellular processes that may indirectly activate HS3ST4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
As an activator of adenylate cyclase, it modulates cAMP levels which may indirectly affect HS3ST4 functioning. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Can influence cellular lipid rafts and membrane-associated processes, potentially affecting HS3ST4 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Another MEK inhibitor, potentially modulating pathways that influence HS3ST4 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor; since PI3K pathway can regulate multiple cellular functions, it might have an indirect effect on HS3ST4 activity. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
By inhibiting calmodulin, it can influence various cellular processes that might in turn modulate HS3ST4 function. | ||||||