HS3ST2 Activators
HS3ST2 activators can be classified into multiple types depending on the pathways they target to bring about HS3ST2 activation. Compounds such as Chlorate and A-769662 serve as metabolic modulators. Chlorate interrupts normal sulfate uptake, causing cells to increase HS3ST2 expression to ensure adequate sulfate conjugation. A-769662 activates AMPK, leading to an upregulation of HS3ST2 as part of cellular energy regulation. Inhibitors of key pathways also constitute another significant category. For example, LY294002 and SB203580 inhibit PI3K and p38 MAPK, respectively. Both proteins negatively regulate HS3ST2, so their inhibition results in its activation.
Forskolin and Rapamycin influence cAMP levels and mTOR signaling, respectively. Both these pathways, when modulated, can lead to HS3ST2 upregulation as part of the cellular stress response. Additionally, compounds like PD98059 and Roscovitine act by disrupting established pathways (MAPK and cell cycle regulation) and thereby push the cells to utilize HS3ST2 as part of their adaptive mechanisms. Therefore, HS3ST2 activators work through a range of biochemical pathways to modulate the protein's activity directly or indirectly.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMPK activator. AMPK activation upregulates HS3ST2 as a part of metabolic regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that disrupts Akt signaling. Akt negatively regulates HS3ST2; thus, its inhibition activates HS3ST2. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Syk inhibitor. Syk signaling indirectly inhibits HS3ST2; its inhibition can thus lead to HS3ST2 activation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor. p38 MAPK negatively regulates HS3ST2, so its inhibition leads to HS3ST2 activation. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Notch signaling inhibitor. Notch signaling suppression can lead to the activation of HS3ST2 in certain cellular contexts. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Adenylyl cyclase activator. Increases cAMP, which can induce HS3ST2 expression via PKA activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor. mTOR inhibition can lead to HS3ST2 upregulation due to cellular stress responses. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
NUAK1 inhibitor. Inhibiting NUAK1 activates AMPK, indirectly leading to HS3ST2 activation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor. Inhibition allows for the compensation by HS3ST2 in MAPK-affected pathways. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
CDK inhibitor, disrupts cell cycle and thereby causing cells to utilize HS3ST2 in cellular response mechanisms. | ||||||