HRC Inhibitors
HRC inhibitors, belonging to a distinct chemical class, are molecules specifically designed to interact with and modulate the activity of a particular cellular component involved in various biological processes. These inhibitors are meticulously crafted to target the unique structural and functional characteristics of the HRC, or "HRC" for short. Researchers have developed these inhibitors through a rigorous process of rational design, utilizing insights from structural biology and computational modeling.
By engaging with the HRC, these molecules have the capacity to exert precise and controlled effects on cellular pathways in which the HRC participates. The interaction between HRC inhibitors and the target molecule is finely tuned to elicit a specific response, potentially leading to intricate downstream effects. This chemical class represents a promising avenue for scientific exploration and has the potential to unveil novel insights into cellular mechanisms and contribute to advancements in various fields of research.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A natural compound found in the Mediterranean plant Thapsia garganica, thapsigargin inhibits the sarco/endoplasmic reticulum calcium ATPase (SERCA) pump, leading to elevated intracellular calcium levels. This disrupts various cellular processes, including those regulated by HRC. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Another SERCA inhibitor, cyclopiazonic acid is a mycotoxin produced by certain fungi. It impairs calcium regulation in cells. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a widely studied inhibitor that affects various calcium channels and pumps, including the endoplasmic reticulum calcium pump (SERCA) and inositol trisphosphate receptors (IP3Rs). | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
This compound acts as a non-specific inhibitor of calcium transporters, including SERCA and IP3Rs, by interfering with their ion conductance. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
A natural product isolated from marine sponges, xestospongin C is a potent inhibitor of IP3Rs, which play a crucial role in calcium release from the endoplasmic reticulum. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Primarily known as a muscle relaxant, dantrolene also inhibits calcium release from the sarcoplasmic reticulum in muscle cells. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Derived from the plant Ryania speciosa, ryanodine is a well-known inhibitor of the ryanodine receptor (RyR), a calcium release channel found in the endoplasmic reticulum. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
TMB-8 is an inhibitor of intracellular calcium release, targeting both IP3Rs and RyRs. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
This synthetic compound blocks store-operated calcium channels (SOCCs), which are crucial for calcium entry into cells upon depletion of intracellular calcium stores. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $89.00 | ||
Gadolinium ions can inhibit various calcium channels and pumps, including stretch-activated calcium channels and SOCCs. | ||||||