HRASLS Activators
The protein HRASLS (HRAS like suppressor) is a member of the HRASLS subfamily of enzymes, also known as PLA/AT enzymes, within the larger family of phospholipase A and acyltransferases. This protein, encoded by the HRASLS gene in humans, is involved in lipid metabolism and has been implicated in apoptosis, or programmed cell death.HRASLS has phospholipase A1/A2 activity, which means it can hydrolyze phospholipids, a major component of cell membranes, at the sn-1 and sn-2 positions. This process generates free fatty acids and lysophospholipids, which serve as lipid mediators in various cellular signaling pathways.
Interestingly, HRASLS also displays acyltransferase activity, allowing it to catalyze the transfer of acyl groups from phospholipids to lysophospholipids. This dual enzymatic activity makes HRASLS unique and suggests its role in lipid remodeling.In the context of disease, HRASLS has been shown to have tumor suppressor activity. It is often downregulated in various cancers, and its overexpression can inhibit proliferation and induce apoptosis in cancer cells. The study of HRASLS involves various techniques like gene overexpression or knockdown to understand its role in cell growth and apoptosis, lipidomic analysis to study its effects on cellular lipid composition, and biochemical assays to characterize its enzymatic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, a PPARα agonist, alters lipid metabolism and might impact HRASLS-related signaling pathways. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPARγ agonist, affects lipid and glucose metabolism, potentially influencing HRASLS function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences lipid metabolism and has anti-inflammatory effects, potentially impacting HRASLS-related pathways. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $252.00 $495.00 | 9 | |
Atorvastatin, a statin, affects cholesterol metabolism and could influence HRASLS-related lipid signaling. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPARγ agonist that impacts lipid metabolism, which might intersect with HRASLS functions. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine influences lipid metabolism and energy utilization, potentially affecting HRASLS-related processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences lipid metabolism and signaling pathways, potentially affecting HRASLS activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, known for its metabolic effects, might influence lipid signaling pathways relevant to HRASLS. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Niacin affects lipid metabolism, particularly in lipid mobilization and utilization, potentially impacting HRASLS. | ||||||