HoxD4 Activators
HoxD4 is a protein encoded by the HOXD4 gene, which is part of the Homeobox gene family. This family is highly conserved across many species and plays a pivotal role in developmental biology. Homeobox genes are known for their involvement in regulating the body plan of the developing embryo, dictating the formation of structures along the anterior-posterior axis.
The HoxD4 protein, like other Homeobox proteins, functions primarily as a transcription factor. It binds to specific DNA sequences and regulates the expression of genes involved in the development of bodily segments. In particular, HoxD4 is crucial in the formation of the vertebral column and the central nervous system. Its expression is tightly controlled both spatially and temporally during embryonic development, ensuring the correct formation of body structures.Mutations or misregulation of the HOXD4 gene can lead to developmental abnormalities. In vertebrates, the precise expression of HoxD4 is essential for the proper development of the cervical and upper thoracic vertebrae. Its role is not just limited to early development; it also has implications in the maintenance of tissue identity and function in adult organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a derivative of Vitamin A and is known to play a crucial role in embryonic development. It could potentially regulate HOXD4 expression as part of its role in patterning and organogenesis. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine could alter the epigenetic state of the HOXD4 gene, potentially leading to its upregulation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, another histone deacetylase inhibitor, could similarly affect chromatin structure and influence HOXD4 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate the Wnt signaling pathway, which is crucial in development and might intersect with HOXD4 regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can influence various signaling pathways and potentially affect HOXD4 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, through its active metabolite, can regulate gene expression and might have a role in influencing HOXD4. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can influence developmental processes and gene expression patterns, potentially affecting HOXD4. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
As a folate antagonist, methotrexate might impact cellular processes and gene expression, potentially influencing HOXD4. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
This inhibitor of the Sonic Hedgehog signaling pathway could potentially have an indirect effect on HOXD4 expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain inhibitor, affects chromatin structure and could influence HOXD4 expression. | ||||||